Immunological and clinical evaluation of local use of Simvastatin in patients with Chronic Periodontitis a randomized double masked clinical trial

Faculdade de Odontologia da Universidade de São Paulo0 个研究点开始时间: 2019年11月18日最近更新: 2023年5月29日

适应症

试验速览

暂无简介。

•Age between 30 years and 70 years. At least 15 teeth in the mouth excluding third molars. Diagnosis of generalized chronic periodontitis according to Armitage et al 1999, which provides for the collection of clinical, radiographic findings and verification of medical and dental history. As clinical periodontal findings, patients should have at least 30% of the periodontal sites with PCS and NCI > 4mm and bleeding on probing. In addition, they should have radiographic evidence of bone loss around the viable teeth. D) Go to scheduled return visits, and should be able to maintain good biofilm control at reevaluations (O'Leary plaque index <30%)

•Patients with medical history linked to systemic diseases. Hypersensitivity to any type of statin. Have used any type of antibiotic for at least 3 months prior to the study. Had peridontal treatment 6 months before the beginning of the trial. Being pregnant and / or breastfeeding. Alcohol users, smokers and ex-smokers (5 years at least). Patients with cancer and / or undergoing chemotherapeutic / radiotherapeutic treatment. Patients diagnosed with aggressive periodontitis. Also excluded from the analyzes dental elements that have pathogenic endodontic ivolvement, third molars and dental implants

发起方

Faculdade de Odontologia da Universidade de São Paulo