NL-OMON52471招募中3 期
Pamidronate for pain in adult chronic nonbacterial osteitis (PAM-CNO): a randomized, double-blind, placebo-controlled trial - PAM-CNO trial
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 70
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Adult patients (> 18 years of age or older) with an established diagnosis of
- •CNO based on clinical imaging features with a reported maximum pain score of
- •6/10 or higher and signs of active disease on imaging, and no treatment with
- •bisphosphonates for the previous 6 months, and willing to participate.
排除标准
- •Patients who are under 18 years of age will be excluded. Active pregnancy wish,
- •pregnancy or nursing are exclusion criteria. Patients with generalized pain
- •without CNO-related pain are excluded. Bisphosphonate use during previous 6
- •months before study entry, bisphosphonate allergy, estimated glomerular
- •filtration rate < 30 ml/min, uncontrolled endocrine abnormalities, and active
- •cancer treatment are exclusion criteria. Patients will not be included in the
- •study in case of language barrier, severe co-morbidity, including poor mobility
- •and other causes preventing attendance for control visits, as are mentally
- •disabled patients. In case of poor dental hygiene or inadequate dental care,
- •patients will only be enrolled after oral maxillary surgeon consultation.
研究者
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