Serotonin and the Upper Airway in Obstructive Sleep Apnea

Phase 4

Completed

• Conditions: Obstructive Sleep Apnea

• Registration Number: NCT00100464
• Lead Sponsor: US Department of Veterans Affairs

Brief Summary

The purpose of this study is to determine if a certain medication, alone or combined with another medication, will increase muscle activity in the upper airway in people who do and people who do not have sleep apnea. The medications being studied are paroxetine, a commonly used antidepressant, and 5 hydroxy-tryptophan (5HTP), which also can be used as a dietary supplement without a prescription. Because the effects of paroxetine in previous studies were not very large, we will also study it combined with 5HTP to see if the effect on the upper airway muscles is greater.

Detailed Description

Not available

Study Timeline

• Study Start: 2000-11
• Primary Completion: 2003-12
• Study Completion: 2003-12
• Study First Submitted: 2004-12-30
• Study First Submitted QC: 2004-12-30
• Study First Posted: 2004-12-31
• Status Verified: 2013-09
• Last Update Submitted: 2013-09-16
• Last Update Posted: 2013-09-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Trial Locations

Locations (1)

Malcolm Randall VA Medical Center; 🇺🇸 Gainesville, Florida, United States