Fluid restriction following open aortic aneurysm surgery
Not Applicable
Completed
- Conditions
- Elective infra-renal aortic aneurysm surgerySurgeryAortic aneurysm surgery
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
Elective patients (aged over 18 years, either sex) undergoing open infra-renal abdominal aortic aneurysm (AAA) repair
Exclusion Criteria
1. Patients undergoing endovascular aortic aneurysm repair
2. Patients undergoing emergency surgery
3. Elective suprarenal AAA repair
4. Severe cardiac failure (New York Heart Association [NYHA] grade IV or myocardial infarction [MI] less than 3 months)
5. Pre-operative serum creatinine greater than 150 mg/dL
6. Pre-operative serum urea greater than 20 mmol/dl
7. Previous history of renal disease
8. Previous renal transplant
9. Patient scheduled to have simultaneous renal procedure at time of surgery
10. Established renal failure requiring renal replacement therapy
11. Previous history of hepatic disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method rinary levels of interleukin-18 (IL-18), neutrophil gelatinase-associate lipocalin (NGAL), retinol binding protein (RBP), albumin/creatinine ratio (ACR), measured at baseline (pre-operative), 6 hours, 12 hours, 24 hours, day 2 ,day 3, day 4, day 5
- Secondary Outcome Measures
Name Time Method All measured as inpatient outcomes:<br>1. All major complications<br>2. Major adverse cardiac event (myocardial infarction, unstable angina, arrhythmia)<br>3. Respiratory complications (including need, duration and extent of ventilatory support)<br>4. Neurological complications (delirium, stroke)<br>5. Mortality<br>6. Length of stay<br>7. Intensive care unit (ITU)/high dependency unit (HDU) stay<br>8. Wound dehiscence<br>9. Gastrointestinal outcome measures:<br>9.1. Time to passage of first flatus<br>9.2. Time to passage of first faeces<br>9.3. Nausea scores<br>9.4. Time to resumption of normal diet