A clinical effectiveness investigation of a multi-faceted intervention (incorporating a prognostic algorithm) to improve management of antibiotics for CHIldren presenting to primary care with acute COugh and respiratory tract infection (CHICO): an efficient cluster RCT informed by a feasibility RCT

niversity of Bristol0 sites294 target enrollmentApril 20, 2018

Overview

2021 Protocol article in https://pubmed.ncbi.nlm.nih.gov/33782018/ (added 31/03/2021) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35777876/ (added 04/07/2022) 2023 Results article in https://doi.org/10.1136/bmj-2022-072488 (added 27/04/2023) 2023 Results article in https://doi.org/10.3310/ucth3411 (added 11/01/2024)

Registry

who.int

Start Date

April 20, 2018

End Date

December 31, 2021

Last Updated

2 years ago

Study Type

Interventional

Sex

All

Sponsor

niversity of Bristol

•The CHICO RCT will recruit GP practices from 15 Clinical Commissioning Groups (CCGs) from demographically diverse regions across England. The population studied will be all children aged 0\-9 years registered at practices using the EMISWeb system. The recruitment of practices will be via CCGs using established channels of communication. An internal pilot phase lasting 3 months and using 3 CCGs will help establish best practice for recruiting and communicating with practices before widening to the remaining CCGs over a staggered 4\-month recruitment period.

•Practices will be asked directly whether they are participating in any antimicrobial stewardship activities during the study period and these will be recorded. If these activities involve concurrent intervention studies where there is potential to confound or modify the effects of our intervention, these practices will be excluded.
•Children aged 10\-14 were considered for inclusion but at this age an increasing number are given antibiotics in tablet form and given the much lower consultation rate in older children the research team decided to exclude this group from the study population.