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Clinical Trials/NCT02004990
NCT02004990
Completed
Not Applicable

Dental Office Prevention Strategies for Children: 10% Povidone Iodine (PI) Cleansing Prior to Fluoride Varnish (FV) Application

University of Minnesota1 site in 1 country12 target enrollmentJanuary 2014
ConditionsDental Plaque

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Dental Plaque
Sponsor
University of Minnesota
Enrollment
12
Locations
1
Primary Endpoint
Dental Plaque Levels Measures on Scale of 0-2
Status
Completed
Last Updated
9 years ago

Overview

Brief Summary

The overall goal of this study is to improve the standard of care in treating young children who often suffer from chronic caries (dental decay). Current standard of care for children under 12 years old includes a dental cleaning and fluoride treatment. Often this dental cleaning includes a 'dental prophylaxis' with a pumice based paste delivered by a small rubber-like cup that rotates on a slow-speed dental handpiece. The procedure of this dental prophylaxis removes the gross levels of plaque around the supragingival tooth surfaces. After this prophylaxis, a fluoride treatment is delivered. The National Maternal and Child Oral Health Resource Center at Georgetown University has published (Bertness J, Holt K) an extensive publication proving that 5% sodium fluoride varnish has become the 'standard of care' for fluoride treatment in children. This study includes this fluoride standard of care.

Prior to the administration of this standard of care fluoride treatment, a separate step of cleansing the tooth after the dental prophylaxis is added. This study uses a cleansing procedure of 10% povidone iodine (PI) cleansing prior to fluoride varnish (FV) application.

The primary aims of this study are:

  1. to measure the changes in overall plaque levels after using a 10% povidone iodine (PI) cleansing prior to fluoride varnish (FV) application.
  2. to measure the short term changes in the oral microbial ecology of dental plaque after 10% povidone iodine (PI) cleansing prior to fluoride varnish (FV) application.
Registry
clinicaltrials.gov
Start Date
January 2014
End Date
November 2015
Last Updated
9 years ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Inclusion criteria: Ages 6-12 years age. Recent history (\< 24 months) of childhood caries, weight ≥ 15 kg, and current dental radiographic films within standard of care practices. At this time, we are looking for longitudinal changes within this cohort and are not using condition-matched controls.

Exclusion Criteria

  • Exclusion criteria: Weight \<15 kg; Iodine or seafood allergy; hypersensitivity to fluoride varnish; antibiotics within the past 3 months; thyroid disease; significant past or current medical problem history, especially conditions that may affect salivary flow, dietary intake patterns, or routine oral hygiene.

Outcomes

Primary Outcomes

Dental Plaque Levels Measures on Scale of 0-2

Time Frame: 2-4 weeks

Modified plaque index for the mixed dentition scale is 0-2 (0=best 2=worse)

Secondary Outcomes

  • Dental Plaque Composition Measured by Numbers of Bacteria Present(2-4 weeks)

Study Sites (1)

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