A Prospective Randomized Comparative Study For Evaluation Of Clinical Efficacy Of Oral Melatonin VS Oral Pregabalin Used As Premedication For Attenuation Of Hemodynamic Response To Laryngoscopy And Endotracheal Intubation In Patients Undergoing Head And Neck Surgery Under General Anaesthesia.

This is prospective, randomized, double-blind interventional study to compare the efficacy of oral melatonin and oral pregabalin as premedication for attenuating the hemodynamic response to laryngoscopy and endotracheal intubation. Ninety ASA I–II patients undergoing elective head and neck surgery under general anesthesia are randomly allocated to receive melatonin, pregabalin, or placebo two hours before surgery.

Hemodynamic parameters, anesthetic drug requirements, and recovery profile is assessed and compared among the groups. The study aims to identify an effective and safe premedication for blunting sympathoadrenal responses during airway manipulation.