NCT00453232已完成2 期
Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 14
- 主要终点
- Toxicity
研究概览
简要总结
RATIONALE: Drugs used in chemotherapy, such as bleomycin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Colony-stimulating factors, such as pegfilgrastim, may increase the number of immune cells found in bone marrow or peripheral blood and may help the immune system recover from the side effects of chemotherapy. Giving combination chemotherapy together with pegfilgrastim may kill more tumor cells.
PURPOSE: This phase II trial is studying the side effects and how well giving combination chemotherapy together with pegfilgrastim works in treating men with metastatic germ cell tumors.
详细描述
OBJECTIVES:
Primary
- Determine the feasibility of accelerated treatment comprising bleomycin, etoposide, cisplatin, and pegfilgrastim in men with metastatic germ cell tumors.
- Determine the toxicity of this regimen (particularly with respect to renal, pulmonary, and neurological function) in these patients.
Secondary
- Determine the response rate in patients treated with this regimen.
- Determine the progression-free survival of patients treated with this regimen.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Toxicity
Feasibility
次要结局
- Response rate
- Progression-free survival
研究者
研究点 (14)
Loading locations...
相似试验
已完成
不适用
Combination Chemotherapy in Treating Children With Newly Diagnosed Malignant Germ Cell TumorsChildhood Germ Cell TumorExtragonadal Germ Cell TumorNCT00066482Children's Oncology Group19
已完成
2 期
G-CSF and Pegfilgrastim in Treating Neutropenia in Patients Undergoing Radiation Therapy and Chemotherapy for Limited Stage Small Cell Lung CancerLung CancerNCT00554463Radiation Therapy Oncology Group5
已完成
3 期
Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the TesticlesDrug/Agent Toxicity by Tissue/OrganTesticular Germ Cell TumorNCT00324298Queen Mary University of London210
已完成
3 期
Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With NeuroblastomaNeuroblastomaNCT00499616Children's Oncology Group464
已完成
3 期
Etoposide and Cisplatin or Carboplatin as First-Line Chemotherapy With or Without Pravastatin in Treating Patients With Small Cell Lung CancerLung CancerNCT00433498University College, London846