ACTRN12619000720112招募中未知
Exploring the role of androgen receptor blockade in increasing the expression of prostate specific membrane antigen (PSMA) and enhancing 68Ga-PSMA-11-PET/CT imaging in patients with metastatic prostate cancer
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- GenesisCare
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Diagnosis
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- Male
入选标准
- •Male, aged 18 years or over
- •Metastatic prostate cancer with demonstrated resistance to standard ADT
- •Eastern Cooperative Oncology Group (ECOG) score 0 or 1 or 2
- •Willing and able to comply with all study requirements, including all imaging and pre- and post-study assessments
- •estimated glomerular filtration rate (eGFR) greater than or equal to 40 mL/min/1.73 m^2
排除标准
- •Prostate cancer with significant neuroendocrine or sarcomatoid component
- •Chemotherapy within previous two months
- •External beam radiotherapy within previous two months
- •Current use of abiraterone, or use within previous two months
- •Known intolerance or hypersensitivity to enzalutamide, or patient in whom enzalutamide is contraindicated
- •Known hypersensitivity to CT imaging intravenous contrast agent
- •Known hypersensitivity to any isotope of Ga in any chemical form, or any of the PSMA-targeting ligands
- •Significant urinary incontinence
- •Any mental condition or cognitive impairment that may render the patient unable to adequately understand the requirements, nature and possible consequences of the study
研究者
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