Investigation of the glycosylation profile of IgG and IgA in saliva and plasma of healthy individuals using liquid chromatography coupled to mass spectrometry (LC-MS)
Completed
- Conditions
- dit onderzoek wordt gedaan in gezonde vrijwilligersnvt
- Registration Number
- NL-OMON43258
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
healthy, between 18 and 50 years of age
Exclusion Criteria
disease, smoking, oral inflammation/wounds
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary study parameters are the differences in glycosylation profiles between<br /><br>saliva- and plasma-derived IgG and IgA.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secundary study parameters are the age and sex of the study participants.</p><br>
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
How does IgG and IgA glycosylation in saliva and plasma correlate with immune function in healthy individuals?
What are the comparative glycosylation profiles of IgG and IgA in saliva vs plasma using LC-MS in NL-OMON43258?
Can IgG/IgA glycosylation patterns serve as biomarkers for early detection of autoimmune diseases?
What adverse events are associated with LC-MS-based glycosylation analysis in observational studies of healthy volunteers?
How do IgG and IgA glycosylation profiles in saliva relate to other immune biomarkers in inflammatory conditions?