Ultrasound Guided Rectus Sheath Block Versus Intrathecal Morphine for Postoperative Analgesia in Patients Undergoing Open Total Abdominal Hysterectomy: A Randomized Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Total morphine consumption
研究概览
简要总结
This study aims to compare the effectiveness and safety of ultrasound-guided rectus sheath block versus intrathecal morphine for postoperative analgesia in patients undergoing open total abdominal hysterectomy.
详细描述
Effective postoperative analgesia is crucial for enhancing recovery and patient satisfaction following major surgical procedures, such as total abdominal hysterectomy (TAH).
Rectus sheath block (RSB), an ultrasound-guided regional anesthesia technique, involves the injection of local anesthetic into the rectus sheath, providing analgesia to the anterior abdominal wall. RSB is used to block the sensory nerves of the anterior abdominal wall and thereby contributing to pain relief after lower abdominal surgeries.
Intrathecal morphine (ITM) provides a highly effective method of analgesia by delivering the medication directly into the cerebrospinal fluid (CSF).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age: 18 - 65 years old.
- •American Society of Anesthesiologists (ASA) physical status (I -II).
- •Patients undergoing open total abdominal hysterectomy.
排除标准
- •Hepatic, renal, or cardiac disease.
- •Any known allergy to local anesthetic.
- •Physical or mental conditions which may vague measuring postoperative pain following surgery.
- •History of chronic use of analgesic as nonsteroidal anti-inflammatory drugs (NSAIDs) or central nervous system (CNS) depressants as antiepileptic, and bleeding disorders.
研究组 & 干预措施
Rectus sheath block group
Patients will receive rectus sheath block (20 ml bilaterally, bupivacaine 0.25%) after induction of general anesthesia.
干预措施: Rectus sheath block (Drug)
Intrathecal morphine group
Patients will receive 150 µg intrathecal morphine after induction of general anesthesia.
干预措施: Intrathecal morphine (Drug)
结局指标
主要结局
Total morphine consumption
时间窗: 24 hours postoperatively
Morphine will be administered if the visual analog scale (VAS) score is ≥ 4.
次要结局
- Time to the first request for the rescue analgesia(24 hours postoperatively)
- Degree of pain(24 hours postoperatively)
- Degree of patient satisfaction(24 hours postoperatively)
- Time of hospital discharge(28 days postoperatively)
- Degree of sedation(Intraoperatively)
- Incidence of adverse events(24 hours postoperatively)
研究者
Sarah Ahmed
Lecturer of Anesthesia, Intensive care, and pain management, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ain Shams University