NL-OMON52890招募中2 期
Deferoxamine in Aneurysmal Subarachnoid Hemorrhage trial - DASH
适应症
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •18-85 years old inclusive,
- •Subarachnoid hemorrhage diagnosed by CT on admission,
- •No history of possible traumatic origin of subarachnoid hemorrhage,
- •Eligible for inclusion within 72 hours of subarachnoid hemorrhage,
- •Saccular intracranial aneurysm proven by cerebral angiography or CTA,
- •Surgical or endovascular obliteration is successfully performed,
- •Able to obtain written informed consent from patient or surrogate,
- •Patients in good clinical grade (WFNS 1-3) (GCS 13-15) at time of inclusion.
排除标准
- •Pregnancy, as confirmed by routine urine test on admission,
- •Abnormal renal function at time of inclusion (eGFR <60 mL/min/1.73m2)
- •Elevated liver function test at time of inclusion (AST > 35 U/L and ALT > 45
- •History of liver disease or active liver or renal disease,
- •Patients with low ferritine (< 20 µg/L),
- •Hypersensitivity to deferoxamine,
- •Patient taking medication not recommended for concomitant use with
- •deferoxamine as per the product label (e.g. high dose vit. C medication).
- •Patients not able to complete the study follow-up.
- •The presence of 4 or more of the following risk modifiers for ARDS prior to
- •enrollment:
- •o Tachypnea (respiratory rate >30),
- •o SpO2 <95%,
- •o Obesity (BMI >30)
- •o Acidosis (pH <7.35),
- •o Hypoalbuminemia (albumin <3.5 g/dL),
- •o Concurrent use of chemotherapy
研究者
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