Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- amplitude of low-frequency fluctuation change before and after light treatment
研究概览
简要总结
It is just an observation study. The investigates want to explore the signal changes of resting state functional Magnetic resonance Imaging (fMRI) after light treatment in jaundice infants. Signal changes contain blood oxygenation level dependent (BOLD) and arterial spin labeling (ASL).Indicator of BOLD is amplitude of low-frequency fluctuation（ALFF).Indicator of ASL is cerebral blood flow (CBF).
The investigates assume that the children with jaundice after light therapy, ALFF and CBF will change. Focus on the globus pallidus and subthalamic nuclei. The two brain regions were proved to be abnormal in MRI T1, T2 structure signal in kernicterus.
Doctors observe the status of infants aside.Using monitoring probe can see clearly.
详细描述
resting state fMRI scan light therapy the second time resting state fMRI scan
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Day 至 28 Days（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hyperbilirubinemia
排除标准
- •cerebral dysgenesis
结局指标
主要结局
amplitude of low-frequency fluctuation change before and after light treatment
时间窗: before and after light treatment
It is indicator of blood oxygenation level dependent.
次要结局
- cerebral blood flow change before after light treatment(before and after light treatment)
研究者
Ya-Fei Zhu
chief physician
Hangzhou Normal University