Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Jaundice
- Sponsor
- Hangzhou Normal University
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- amplitude of low-frequency fluctuation change before and after light treatment
- Last Updated
- 11 years ago
Overview
Brief Summary
It is just an observation study. The investigates want to explore the signal changes of resting state functional Magnetic resonance Imaging (fMRI) after light treatment in jaundice infants. Signal changes contain blood oxygenation level dependent (BOLD) and arterial spin labeling (ASL).Indicator of BOLD is amplitude of low-frequency fluctuation（ALFF).Indicator of ASL is cerebral blood flow (CBF).
The investigates assume that the children with jaundice after light therapy, ALFF and CBF will change. Focus on the globus pallidus and subthalamic nuclei. The two brain regions were proved to be abnormal in MRI T1, T2 structure signal in kernicterus.
Doctors observe the status of infants aside.Using monitoring probe can see clearly.
Detailed Description
resting state fMRI scan light therapy the second time resting state fMRI scan
Investigators
Ya-Fei Zhu
chief physician
Hangzhou Normal University
Eligibility Criteria
Inclusion Criteria
- •hyperbilirubinemia
Exclusion Criteria
- •cerebral dysgenesis
Outcomes
Primary Outcomes
amplitude of low-frequency fluctuation change before and after light treatment
Time Frame: before and after light treatment
It is indicator of blood oxygenation level dependent.
Secondary Outcomes
- cerebral blood flow change before after light treatment(before and after light treatment)