Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment.

• Conditions: Jaundice

• Registration Number: NCT02224586
• Lead Sponsor: Hangzhou Normal University

Brief Summary

It is just an observation study. The investigates want to explore the signal changes of resting state functional Magnetic resonance Imaging (fMRI) after light treatment in jaundice infants. Signal changes contain blood oxygenation level dependent (BOLD) and arterial spin labeling (ASL).Indicator of BOLD is amplitude of low-frequency fluctuation（ALFF).Indicator of ASL is cerebral blood flow (CBF).

The investigates assume that the children with jaundice after light therapy, ALFF and CBF will change. Focus on the globus pallidus and subthalamic nuclei. The two brain regions were proved to be abnormal in MRI T1, T2 structure signal in kernicterus.

Doctors observe the status of infants aside.Using monitoring probe can see clearly.

Detailed Description

resting state fMRI scan light therapy the second time resting state fMRI scan

Study Timeline

• Status Verified: 2014-08
• Study Start: 2014-08
• Study First Submitted: 2014-08-20
• Study First Submitted QC: 2014-08-21
• Last Update Submitted: 2014-08-21
• Study First Posted: 2014-08-25
• Last Update Posted: 2014-08-25
• Primary Completion: 2015-03
• Study Completion: 2015-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• hyperbilirubinemia

Exclusion Criteria

• asphyxia
• cerebral dysgenesis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
amplitude of low-frequency fluctuation change before and after light treatment	before and after light treatment	It is indicator of blood oxygenation level dependent.

Secondary Outcome Measures

Name	Time	Method
cerebral blood flow change before after light treatment	before and after light treatment	It is indicator of arterial spin labeling.

Trial Locations

Locations (1)

Center for Cognition and Brain Disorders; 🇨🇳 Hangzhou, Zhejiang, China