High Fructose Corn Syrup

Not Applicable

Completed

• Conditions: Obesity; Nonalcoholic Fatty Liver Disease

• Registration Number: NCT02018237
• Lead Sponsor: Washington University School of Medicine

Brief Summary

The purpose of this research study is to learn more about how high fructose corn syrup, a sugar used to sweeten drinks and foods, affects metabolism in obese persons with and without nonalcoholic fatty liver disease. Eligible participants will be studied before and after eating a diet high in high fructose corn syrup or a standard diet (low in high fructose corn syrup) for four weeks.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03
• Study First Submitted: 2013-12-17
• Study First Submitted QC: 2013-12-17
• Study First Posted: 2013-12-23
• Primary Completion: 2016-03
• Study Completion: 2016-03
• Status Verified: 2017-03
• Last Update Submitted: 2017-03-22
• Last Update Posted: 2017-03-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 47

Inclusion Criteria

• IHTG >6.5% or <5%
• BMI 30.0-45.0 kg/m²
• Sedentary
• Consume <10% calories from high fructose corn syrup
• Weight stable for previous 3 months

Exclusion Criteria

• IHTG 5.1-7.9%
• Children
• Adults over 65 years
• Pregnant
• Lactating
• Exercise >1.5 hours/week
• Hepatitis B or C
• Diabetes
• History of liver disease
• History of alcohol abuse
• Severe hypertriglyceridemia (>300 mg/dl)
• Smokers
• Anemia (Hemoglobin <10mg/dl)
• Not weight stable

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Hepatic lipid metabolism	4 weeks	Determine the effect of 4-week isocaloric diet high in HFCS on hepatic lipid metabolism \[de novo lipogenesis, very low density lipoprotein-triglyceride (VLDL-TG) and very low density lipoprotein-Apolipoprotein B100 (VLDL-ApoB) secretion rates\] by using stable isotope tracer methods.
Multi-organ insulin sensitivity	4 weeks	Determine the effect of 4-week isocaloric diet high in HFCS on multi-organ insulin sensitivity by using a one stage hyperinsulinemic euglycemic clamp procedure in conjunction with muscle and adipose tissue biopsies.
Change in intrahepatic triglyceride (IHTG) content	4 weeks	Determine the effect of 4-week isocaloric diet high in high fructose corn syrup (HFCS) on IHTG content measured by magnetic resonance spectroscopy (MRS).
Uric acid metabolism	4 weeks	Determine the effect of 4-week isocaloric diet high in HFCS on uric acid metabolism by measuring post-prandial serum uric acid concentrations and using stable isotope tracer method.

Trial Locations

Locations (1)

Washington University School of Medicine; 🇺🇸 St. Louis, Missouri, United States