High Fructose Corn Syrup

Not Applicable

Completed

• Conditions: Obesity; Nonalcoholic Fatty Liver Disease
• Interventions: Behavioral: High fructose corn syrup diet; Behavioral: Standard diet (low in high fructose corn syrup)

• Registration Number: NCT02018237
• Lead Sponsor: Washington University School of Medicine

Brief Summary

The purpose of this research study is to learn more about how high fructose corn syrup, a sugar used to sweeten drinks and foods, affects metabolism in obese persons with and without nonalcoholic fatty liver disease. Eligible participants will be studied before and after eating a diet high in high fructose corn syrup or a standard diet (low in high fructose corn syrup) for four weeks.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03
• Study First Submitted: 2013-12-17
• Study First Submitted QC: 2013-12-17
• Study First Posted: 2013-12-23
• Primary Completion: 2016-03
• Study Completion: 2016-03
• Status Verified: 2017-03
• Last Update Submitted: 2017-03-22
• Last Update Posted: 2017-03-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 47

Inclusion Criteria

• IHTG >6.5% or <5%
• BMI 30.0-45.0 kg/m²
• Sedentary
• Consume <10% calories from high fructose corn syrup
• Weight stable for previous 3 months

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Exclusion Criteria

• IHTG 5.1-7.9%
• Children
• Adults over 65 years
• Pregnant
• Lactating
• Exercise >1.5 hours/week
• Hepatitis B or C
• Diabetes
• History of liver disease
• History of alcohol abuse
• Severe hypertriglyceridemia (>300 mg/dl)
• Smokers
• Anemia (Hemoglobin <10mg/dl)
• Not weight stable

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
NAFLD	Standard diet (low in high fructose corn syrup)	Subjects with nonalcoholic fatty liver disease (NAFLD) will complete baseline testing and then be assigned to either the high fructose corn syrup diet or the standard diet (low in high fructose corn syrup) for 4 weeks. Post intervention testing will be completed after the subjects have completed the 4 week diet intervention.
NAFLD	High fructose corn syrup diet	Subjects with nonalcoholic fatty liver disease (NAFLD) will complete baseline testing and then be assigned to either the high fructose corn syrup diet or the standard diet (low in high fructose corn syrup) for 4 weeks. Post intervention testing will be completed after the subjects have completed the 4 week diet intervention.
Non-NAFLD	High fructose corn syrup diet	Subjects without nonalcoholic fatty liver disease (Non-NAFLD) will complete baseline testing and then be fed a high fructose corn syrup diet for 4 weeks. Post intervention testing will be completed after the subjects have completed the 4 week diet intervention.

Primary Outcome Measures

Name	Time	Method
Hepatic lipid metabolism	4 weeks	Determine the effect of 4-week isocaloric diet high in HFCS on hepatic lipid metabolism \[de novo lipogenesis, very low density lipoprotein-triglyceride (VLDL-TG) and very low density lipoprotein-Apolipoprotein B100 (VLDL-ApoB) secretion rates\] by using stable isotope tracer methods.
Multi-organ insulin sensitivity	4 weeks	Determine the effect of 4-week isocaloric diet high in HFCS on multi-organ insulin sensitivity by using a one stage hyperinsulinemic euglycemic clamp procedure in conjunction with muscle and adipose tissue biopsies.
Change in intrahepatic triglyceride (IHTG) content	4 weeks	Determine the effect of 4-week isocaloric diet high in high fructose corn syrup (HFCS) on IHTG content measured by magnetic resonance spectroscopy (MRS).
Uric acid metabolism	4 weeks	Determine the effect of 4-week isocaloric diet high in HFCS on uric acid metabolism by measuring post-prandial serum uric acid concentrations and using stable isotope tracer method.

Trial Locations

Locations (1)

Washington University School of Medicine; 🇺🇸 St. Louis, Missouri, United States