The Effect of High Fructose Corn Syrup Feeding in Nonalcoholic Fatty Liver Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 2
- 主要终点
- Hepatic lipid metabolism
研究概览
简要总结
The purpose of this research study is to learn more about how high fructose corn syrup, a sugar used to sweeten drinks and foods, affects metabolism in obese persons with and without nonalcoholic fatty liver disease. Eligible participants will be studied before and after eating a diet high in high fructose corn syrup or a standard diet (low in high fructose corn syrup) for four weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •IHTG >6.5% or <5%
- •BMI 30.0-45.0 kg/m²
- •Sedentary
- •Consume <10% calories from high fructose corn syrup
- •Weight stable for previous 3 months
排除标准
- •IHTG 5.1-7.9%
- •Adults over 65 years
- •Lactating
- •Exercise >1.5 hours/week
- •Hepatitis B or C
- •History of liver disease
- •History of alcohol abuse
- •Severe hypertriglyceridemia (>300 mg/dl)
- •Anemia (Hemoglobin <10mg/dl)
- •Not weight stable
结局指标
主要结局
Hepatic lipid metabolism
时间窗: 4 weeks
Determine the effect of 4-week isocaloric diet high in HFCS on hepatic lipid metabolism \[de novo lipogenesis, very low density lipoprotein-triglyceride (VLDL-TG) and very low density lipoprotein-Apolipoprotein B100 (VLDL-ApoB) secretion rates\] by using stable isotope tracer methods.
Multi-organ insulin sensitivity
时间窗: 4 weeks
Determine the effect of 4-week isocaloric diet high in HFCS on multi-organ insulin sensitivity by using a one stage hyperinsulinemic euglycemic clamp procedure in conjunction with muscle and adipose tissue biopsies.
Change in intrahepatic triglyceride (IHTG) content
时间窗: 4 weeks
Determine the effect of 4-week isocaloric diet high in high fructose corn syrup (HFCS) on IHTG content measured by magnetic resonance spectroscopy (MRS).
Uric acid metabolism
时间窗: 4 weeks
Determine the effect of 4-week isocaloric diet high in HFCS on uric acid metabolism by measuring post-prandial serum uric acid concentrations and using stable isotope tracer method.
次要结局
未报告次要终点