Personalized Inhibitory Control Training for Compulsive Behavior Change
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- OCD
- Sponsor
- Hebrew University of Jerusalem
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- fMRI- changed inhibition levels in the pre-SMA area in experimental group in comparison to control group
- Last Updated
- 7 years ago
Overview
Brief Summary
Obsessive-compulsive disorder (OCD) is a severe mental illness characterized by repetitive behaviors that a person feels compelled to perform. It has been demonstrated that stimuli in the environment can trigger the compulsive urge, perpetuating the OCD cycle. The main goal of the current proposal, which is based on exciting pilot data, is to test a novel computerized training program to create an association between OCD-related stimuli, which typically trigger the compulsive urge, and the brain system responsible for stopping. The idea is that once this system is triggered, it will be easier for patients to stop the compulsive urge.
Investigators
Shahaf Leshem
Principal investigator
Hebrew University of Jerusalem
Eligibility Criteria
Inclusion Criteria
- •OCD patients
Exclusion Criteria
- •Metal/ electronic device
- •Under the age of 18
- •Pregnant women
- •Tattoos that cover over 10% of body mass
- •Chronically ill patients
- •Psychosis/ Bi-polar
- •Substance abuse
- •Sever depression
- •Active suicide thoughts
- •Hearing loss
Outcomes
Primary Outcomes
fMRI- changed inhibition levels in the pre-SMA area in experimental group in comparison to control group
Time Frame: One week after P-CIT training starts
During tasks that require inhibition
fMRI- changed inhibition levels in the rIFG area in experimental group in comparison to control group
Time Frame: One week after P-CIT training starts
During tasks that require inhibition
Secondary Outcomes
- Behavioural- Y-bocs (Yale-Brown Obsessive-Compulsive Scale) score- change in OCD symptoms in experimental group in comparison to placebo group(One week after P-CIT (Personalized Inhibitory Control Training for Compulsive Behavior Change) training)
- Behavioural- OCI-R (Obsessive-Compulsive Inventory) score- change in OCD symptoms in experimental group in comparison to placebo group(One week after P-CIT (Personalized Inhibitory Control Training for Compulsive Behavior Change) training)
- Behavioural- M.I.N.I (Mini-International Neuropsychiatric Interview) score- change in OCD symptoms in experimental group in comparison to placebo group(One week after P-CIT (Personalized Inhibitory Control Training for Compulsive Behavior Change) training)