Rumination: Mechanism of the antidepressant effect of exercise? Development of a decoder for the prediction of rumination during exercise

Not Applicable

• Conditions: DSM-V: F32.1 - F32.2; DSM-V: F33.1 - F33.2; F32.1; F32.2; F33.1; F33.2; Moderate depressive episode; Severe depressive episode without psychotic symptoms; Recurrent depressive disorder, current episode moderate; Recurrent depressive disorder, current episode severe without psychotic symptoms

• Registration Number: DRKS00022386
• Lead Sponsor: Eberhard Karls Universität Tübingen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-08-06
• Study Completion: 2022-03-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

informed, written consent;
currently diagnosed moderate depression diagnosed with SKID-V (F32.1-F32.1, F33.1-F33.2);
BDI-II Score > 20;
Age between 18-40 years;
fluent german skills;
no psychopharmacological treatment;
waiting period for ambulant psychotherapy > 2 months

Exclusion Criteria

acute suicidality;
schizophrenia and other psychotic disorders (F23, F20.81, F20.9 DSM-V);
acute substance misuse except for tabacco (F10, F11, F12, F13, F14, F15, F16, F18, F19 DSM-V);
current psychotherapy or start during the study period;
current psychopharmacological treatment or start during study period;
regular exercise (more then once a week for 30 minutes at a time endurance orientated exercise; e.g. jogging, cycling, swimming);
acute or chronic diseases influencing brain metabolism:
diabetes mellitus (E10-E14 ICD-10),
kidney insufficiency from stadium 3 of the kidney disease outcome quality initative,
non-adjusted hypertension (I10.x ICD-10), moderate to severe craniocerebral trauma (GSC 3-12) or rather craniocerebral trauma second or third degree with loss of concouisness for more than 30 minutes;
medical contraindications for exercise:
acute infectious diseases, medication intake, which in the opinion of the study physician do not permit an inclusion,
allergic diseases in an acute episode,
severe metabolic diseases,
non-adjusted hypertension,
cardiovascular diseases,
orthopedic symptoms, which in the opinion of the study physician do not permit an inclusion

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Decoders, which have been trained for each subject individually, are used to decode neurophysiological data (EEG, fNIRS) during exercise. It is then compared how often rumination, distraction and positive mood are decoded during active conditions (MVPA, AIT) compared to the inactive control condition. Furthermore, it is considered how decoded severity of rumination differs between the three conditions.

Secondary Outcome Measures

Name	Time	Method
Additionally to the decoders subjective data should be included. Therfore questionnaires concerning rumination and affect are executed before and after exercise (Perservative Thinking Questionnaire - State; Positive and Negative Affect Schedule). It is considered to what extent the questionnaires concerning rumination and affect differ in the active conditions (MVPA, AIT) compared to the inactive control condition.