Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Progression in total cerebral small vessel disease burden
研究概览
简要总结
The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing biomarkers for the early prevention and treatment of cerebrovascular disease.
详细描述
Cerebrovascular disease is the most common cause of death worldwide. There is a close link in structure and function between the intracranial large arteries and cerebral small vessels. Moreover, growing evidences have demonstrated that large artery atherosclerosis often coexists with small vessel disease, which may deteriorate the clinical outcomes of stroke and dementia. The mutual feedback mechanism between them is not fully understood. The present study focuses on the mechanism of mutual feedback between large artery atherosclerosis and cerebral small vessel disease by using magnetic resonance imaging. The study may provide biomarkers for the early prevention and treatment of cerebrovascular disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •At least one intracranial artery ≥ 50% atherosclerotic stenosis
- •Modified Rankin Scale < 2
- •Mini-mental State Examination > 24
排除标准
- •Concurrent ipsilateral extracranial artery ≥ 50% stenosis
- •Pregnant women
- •Contraindications to magnetic resonance examination (patients with pacemakers, nerve stimulators, artificial metal heart valves and other metal foreign bodies)
结局指标
主要结局
Progression in total cerebral small vessel disease burden
时间窗: 1-3 YEARS
Total cerebral small vessel disease burden is assessed according to a sum of scores of white matter hyperintensity, cerebral microbleeds, lacunes and enlarged perivasular spaces on magnetic resonance imaging sequences.
Frequency of stroke recurrence
时间窗: 1-3 YEARS
The percentage of symptomatic participants who suffer from stroke recurrence after enrollment in the territory of the targeted stenotic vessel.
次要结局
- Frequency of stroke of asymptomatic participants(1-3 YEARS)
研究者
Jinhao Lyu
Attending physician
Chinese PLA General Hospital