Isometric Exercise in NTG
- Conditions
- Mean Blur Ratio
- Interventions
- Diagnostic Test: Isometric exercise
- Registration Number
- NCT03921372
- Lead Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
- Brief Summary
Glaucoma is the second leading cause of blindness worldwide. Literature shows increasing evidence that dysfunction of ocular microcirculation in the optic nerve influences the progression of glaucoma. It has been shown that flicker light-induced vasodilatation of retinal veins is diminished in patients with glaucoma. Also previous studies indicate that the blood flow autoregulation is impaired in patients with glaucoma. Therefor the ocular perfusion pressure can not be maintained stable during changes of the systemic arterial blood pressure. Laser speckle flowgraphy (LSFG) represents a non-invasive method to quantify ocular perfusion also at the ONH. LSFG enables noninvasive quantification of microcirculation of the optic disc in Japanese glaucoma patients.
Study Objectives:
To assess the changes in LSFG parameters in patients with normal tension glaucoma, compared to healthy subjects during flicker light stimulation and isometric exercises.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
Not provided
-
a) Study population: patients with normal tension glaucoma
-
History of ocular or systemic disease causing optic nerve damage
-
History of IOP greater than 21 mm Hg (corrected by CCT)
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Participation in a clinical trial in the 3 weeks preceding the study
-
Ocular surgery (including intravitreal injection) during the 3 months preceding the study
-
Ametropia > 6 Dpt
-
Smoking
-
pre- or perimenopausal women
-
Relevant ophthalmic diseases/conditions that could interfere with LSFG measurements (e.g. optic nerve head drusen, tilted disc, etc.)
-
Opacities of the cornea (e.g. corneal scars, corneal oedema), the lens (e.g. LOCS-II grading > 2, posterior capsule opacification) or the vitreous (e.g. vitreous haemorrhage, asteroid hyalosis)
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Patients who are not able to cooperate or with insufficient ability to fixate (tremor, nystagmus)
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Blood donation in the 3 weeks preceding the study
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Symptoms of a clinically relevant illness in the 3 weeks before the first study day
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Ocular infection or clinically significant inflammation
-
Pregnancy, planned pregnancy or lactating
b) Control group
-
Abnormal RNFL
-
Visual field defects
-
Participation in a clinical trial in the 3 weeks preceding the study
-
Ocular surgery (including intravitreal injection) during the 3 months preceding the study
-
Ametropia > 6 Dpt
-
Smoking
-
Relevant ophthalmic diseases/conditions that could interfere with LSFG measurements (e.g. optic nerve head drusen, tilted disc, etc.)
-
Opacities of the cornea (e.g. corneal scars, corneal oedema), the lens (e.g. LOCS-II grading > 2, posterior capsule opacification) or the vitreous (e.g. vitreous haemorrhage, asteroid hyalosis)
-
Patients who are not able to cooperate or with insufficient ability to fixate (tremor, nystagmus)
-
Blood donation in the 3 weeks preceding the study
-
Symptoms of a clinically relevant illness in the 3 weeks before the first study day
-
Ocular infection or clinically significant inflammation
-
Pregnancy, planned pregnancy or lactating
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Normal Tension Glaucoma (NTG) Isometric exercise Patients with diagnosed NTG Healthy Control Subjects Isometric exercise Subjects with no sign of glaucoma, Age and sex matched
- Primary Outcome Measures
Name Time Method Change in mean blur rate 5 minutes
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
AKh Linz
🇦🇹Linz, Oberösterreich, Austria