Multiple Biomarkers in ICU Sepsis Patients

• Conditions: Septic Shock; Sepsis, Severe; Sepsis; AKI

• Registration Number: NCT03802136
• Lead Sponsor: Zhongnan Hospital

Brief Summary

Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality. Oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. Some biomarkers would be able to identify who will recover and not recover better than serum creatinine. Thus, a combining oxidative stress biomarkers are needed to predict the occurrence or progression of AKI in critically ill patients.

Detailed Description

Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality. Oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. Research on AKI has focused on new damage biomarkers for early detection of AKI and worsening of renal function. Some biomarkers would be able to identify who will recover and not recover better than serum creatinine. Thus, a combining functional and damage markers as well as oxidative stress biomarkers are needed to predict the occurrence or progression of AKI in critically ill patients. Therefore, this prospective, observational study will be conducted in Mainland China

Study Timeline

• Study Start: 2018-12-30
• Status Verified: 2019-01
• Study First Submitted: 2019-01-02
• Study First Submitted QC: 2019-01-11
• Last Update Submitted: 2019-01-11
• Study First Posted: 2019-01-14
• Last Update Posted: 2019-01-14
• Primary Completion: 2019-06
• Study Completion: 2019-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• sepsis patients in appropriate age

Exclusion Criteria

• ever blood transfusion ever CPR（cardiopulmonary resuscitation)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Death of the patients	2 weeks after admission to ICU	Mortality of the studied patients
presence of AKI	a week after admission to ICU	Use serum creatinine or urine output（The KDIGO Guidelines 2012) to asess whether AKI happens to the studied subjects within a week after admission to ICU

Secondary Outcome Measures

Name	Time	Method
Use serum creatinine to assess renal function of the patients	the 1 day when the patients admitted to ICU	Concetration of serum creatinine

Trial Locations

Locations (1)

Zhongnan Hospital of Wuhan University; 🇨🇳 Wuhan, Hubei, China