Effect of Exercise, Endocannabinoids and Ketones on Cerebral Metabolism in a Cognitive Disorders Population

Not Applicable

Active, not recruiting

• Conditions: Alzheimer Disease; Parkinson Disease
• Interventions: Dietary Supplement: Betaquik MCT supplement

• Registration Number: NCT04322461
• Lead Sponsor: Université de Sherbrooke

Brief Summary

A two months intervention in which two groups of cognitive disorders, Parkinson and Alzheimer's disease, will receive 50g/day of a commercial MCT supplement combined with supervised aerobic exercise 3 times/week. Cognition and ketones will be assess before and after the intervention, along with endocannabinoids plasma concentrations.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-03-24
• Study First Submitted QC: 2020-03-24
• Study First Posted: 2020-03-26
• Study Start: 2022-05-01
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-30
• Last Update Posted: 2024-05-31
• Primary Completion: 2024-08-15
• Study Completion: 2024-12-15

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Alzheimer's or parkinson disease diagnostic
• Stable medication associated with the disease
• Able to consent
• Presence of an accompanying person for the first and last visit.
• Ability to read and talk in French

Exclusion Criteria

• MMSE < 20
• MCT or coconut oil supplementation
• Coconut allergy
• Cannabis, THC or CBD consumption
• Excessive alcohol consumption
• Physical activity 3x/week
• Presence of an metallic object in the body
• Impossibility to lay in dorsal decubitus for 40 minutes
• Cardiac disease
• Any uncontrolled disease that could interfer with the project.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Alzheimer's disease	Betaquik MCT supplement	2 months intervention with 50g/day of a commercial MCT supplement combine with supervised aerobic exercise 3x/week.
Parkinson disease	Betaquik MCT supplement	2 months intervention with 50g/day of a commercial MCT supplement combine with supervised aerobic exercise 3x/week.

Primary Outcome Measures

Name	Time	Method
Ketones	2 months, evaluation before and after intervention	Measurement of ketones concentrations
Cognition	2 months, evaluation before and after intervention	Measure of cognition with CANTAB

Secondary Outcome Measures

Name	Time	Method
Endocannabinoids	2 months, evaluation before and after intervention	Endocannabinoids plasma concentration

Trial Locations

Locations (1)

Centre de recherche sur le vieillissement; 🇨🇦 Sherbrooke, Quebec, Canada