NCT04322461已完成不适用
Effect of Exercise, Endocannabinoids and Ketones on Cerebral Metabolism in a Cognitive Disorders Population : Pilot Project PARKA
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Cognition
研究概览
简要总结
A two months intervention in which two groups of cognitive disorders, Parkinson and Alzheimer's disease, will receive 50g/day of a commercial MCT supplement combined with supervised aerobic exercise 3 times/week. Cognition and ketones will be assess before and after the intervention, along with endocannabinoids plasma concentrations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Alzheimer's or parkinson disease diagnostic
- •Stable medication associated with the disease
- •Able to consent
- •Presence of an accompanying person for the first and last visit.
- •Ability to read and talk in French
排除标准
- •MMSE < 20
- •MCT or coconut oil supplementation
- •Coconut allergy
- •Cannabis, THC or CBD consumption
- •Excessive alcohol consumption
- •Physical activity 3x/week
- •Presence of an metallic object in the body
- •Impossibility to lay in dorsal decubitus for 40 minutes
- •Cardiac disease
- •Any uncontrolled disease that could interfer with the project.
结局指标
主要结局
Cognition
时间窗: 2 months, evaluation before and after intervention
Measure of cognition with CANTAB
Ketones
时间窗: 2 months, evaluation before and after intervention
Measurement of ketones concentrations
次要结局
- Endocannabinoids(2 months, evaluation before and after intervention)
研究者
研究点 (2)
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