ACTRN12611001021965已完成2 期
A pilot randomised trial comparing the inflammatory response to hypertonic saline versus normal saline as the initial fluid bolus in adults presenting to the emergency department with presumed early sepsis
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 65
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 16 Years 至 o limit（—）
- 性别
- All
入选标准
- •1. Suspected or proven infection
- •2. Two or more SIRS criteria (HR>90/min, RR>20/min, T>38 deg C, WCC>12 (or temp<36 deg C and WCC<4))
- •3. Fluid bolus indicated clinically
- •4. Informed consent
排除标准
- •1. Contraindication to volume loading (e.g. coexistent acute pulmonary oedema)
- •2. Severe hypotension (SBP<90) requiring immediate resuscitation
- •3. Plasma sodium concentration outside normal range (135-145 mEq/L)
- •4. Established significant metabolic acidosis (venous pH <7.25)
- •5. Established significant renal failure eGFR < 45 mL/min/1.73m2
- •6. Pregnancy
- •7. Age less than 16 years of age
- •8. Deemed for palliative/supportive care only
- •9. Received prehospital IV fluids >500 mL in total
研究者
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