Prospective Validation of CARPET Prognostic Model for Septic Shock After Allo-HSCT
- Conditions
- Stem Cell Transplant Complications
- Interventions
- Other: CARPET prognostic model
- Registration Number
- NCT06022445
- Lead Sponsor
- Peking University People's Hospital
- Brief Summary
Validation of CARPET prognostic model for septic shock after allo-HSCT: a multicenter, prospective, and cohort study
- Detailed Description
A clinical prognostic model named CARPET model for septic shock after allo-HSCT has been developed and internally retrospectively validated. A multicenter, prospective cohort study is planned to validate this clinical prediction model again.
The equation of the prediction model for 28-day mortality was as follows:
Probability(28-day mortality)=(exp(Y))/(1+exp(Y)) where Y=2.343+1.328\* Time of septic shock- 0.085\* Albumin + 0.016 \* Bilirubin-0.003\*PaO2/FiO2 +0.127\*Lactate- 0.011 \* Glomerular filtration rate
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 200
- age >18 years
- underwent allo-HSCT
- diagnosed with septic shock
- experienced septic shock before enrollment
- relapsed or progressed after HSCT
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients with septic shock after allo-HSCT CARPET prognostic model patients who underwent allo-HSCT and experienced septic shock
- Primary Outcome Measures
Name Time Method 28-day mortality 28 days Dead or alive at day 28 after septic shock diagnosis
- Secondary Outcome Measures
Name Time Method ICU length of stay up to 1 year Days in the ICU after septic shock diagnosis
Time on ventilator up to 1 year Days in need of mechanical ventilation
90-day mortality 90 days Dead or alive at day 90 after septic shock diagnosis
Trial Locations
- Locations (1)
Peking University Insititute of Hematology, Peking University People's Hospital
🇨🇳Beijing, Beijing, China