Prospective Validation of CARPET Prognostic Model for Patients With Septic Shock After Allogeneic Hematopoietic Stem Cell Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- 28-day mortality
研究概览
简要总结
Validation of CARPET prognostic model for septic shock after allo-HSCT: a multicenter, prospective, and cohort study
详细描述
A clinical prognostic model named CARPET model for septic shock after allo-HSCT has been developed and internally retrospectively validated. A multicenter, prospective cohort study is planned to validate this clinical prediction model again.
The equation of the prediction model for 28-day mortality was as follows:
Probability(28-day mortality)=(exp(Y))/(1+exp(Y)) where Y=2.343+1.328* Time of septic shock- 0.085* Albumin + 0.016 * Bilirubin-0.003*PaO2/FiO2 +0.127*Lactate- 0.011 * Glomerular filtration rate
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age >18 years
- •underwent allo-HSCT
- •diagnosed with septic shock
排除标准
- •experienced septic shock before enrollment
- •relapsed or progressed after HSCT
结局指标
主要结局
28-day mortality
时间窗: 28 days
Dead or alive at day 28 after septic shock diagnosis
次要结局
- ICU length of stay(up to 1 year)
- Time on ventilator(up to 1 year)
- 90-day mortality(90 days)
研究者
Xiao Hui Zhang
Vice president of Peking University Institute of Hematology
Peking University People's Hospital