Magnetic Resonance Image Guided Single Fraction Preoperative Radiotherapy for Early Breast Cancer

Not Applicable

• Conditions: Early Breast Cancer; Cancer - Breast

• Registration Number: ACTRN12621000659808
• Lead Sponsor: Olivia Newton-John Cancer Research Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-05-31
• Last Update Posted: 7 June 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

1.Age 60 years or older
2.Unifocal Breast Cancer
3.Tumour Size on pre-treatment imaging equal to or greater than 2 cm
4.Grade <3 on pre-treatment core biopsy
5.Oestrogen receptor (ER) and Progesterone (PR) positive (>10%)
6.Clinically node negative
7. Willing and able to provide informed consent

Exclusion Criteria

1.Previous RT to same breast
2.Suspicious diffuse microcalcifications
3.Invasive lobular carcinoma on core biopsy
4.Lymphovascular invasion on core biopsy
5.Any clinical nodal or metastatic disease
6.HER2 positive
7.Prior non-hormonal therapy
8.Skin or chest wall involvement
9.Collagen vascular disease, e.g. lupus, scleroderma
10.Pregnant or lactating
11.Contraindications to MRI e.g. pacemaker, severe claustrophobia
12. Unable or unwilling to provide informed consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified