Effects of Cardiac Rehabilitation for Individuals With Transient Ischemic Attack
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Functional Walk Test
Study Overview
Brief Summary
It is hypothesized that the addition of formal cardiac rehabilitation to standard care will result in long-term improvements in cardiovascular fitness and functional capacity in individuals who have suffered a transient ischemic attack (TIA) or minor stroke.
Furthermore, it is proposed that the addition of cardiac rehabilitation will influence depressive symptoms and cognition.
Detailed Description
A transient ischemic attack (TIA) is defined as an episode of neurological dysfunction caused by focal brain ischemia lasting less than 24 hours. Once an individual has suffered a TIA, preventative measures can be taken to target modifiable risk factors, one of which is physical inactivity. The current proposal focuses on the use of an established model of care (cardiac rehabilitation (CR)) and applies it to those who have suffered a TIA in order to maximize physical activity and minimize risk of future cardiovascular events. This will be a one-group pre/post design study with a 3 month non-intervention period. Participants will undergo measures at baseline and 3 months (non intervention period) then after 6 months of cardiac rehabilitation (cardiovascular fitness, 6 minute walk test, cognition, and depressive symptoms).
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 100 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Diagnosed with TIA
- •Three months post-TIA
- •Ability to understand the process and instructions for exercise training and provide informed consent
Exclusion Criteria
- •Resting Blood Pressure greater than 160/100 despite medication
- •Other cardiovascular morbidity which would limit exercise tolerance (heart failure, abnormal BP responses or STsegment depression > 2 mm, symptomatic aortic stenosis, complex arrhythmias)
- •Current and extensive exercise participation
- •Hypertrophic Cardiomyopathy
- •Unstable Angina
- •Orthostatic BP decrease of > 20 mm Hg with symptoms
- •Other musculoskeletal impairments which would limit the participants ability to walk sufficient durations
- •Pain or other co-morbidities (e.g., unclipped aneurysms, uncontrolled seizures etc.) which would preclude participation
- •Cognitive or behavioural issues that would limit participation in exercise testing and training
Outcomes
Primary Outcomes
Functional Walk Test
Time Frame: Baseline, 3 months, 6 months (Six Minute Walk Distance)
6 minute walk test: the longest distance a person can walk for a duration of 6 minutes
Cardiovascular Fitness (VO2peak)
Time Frame: Baseline (after the 3 month non-intervention period) and after 6 months of participation.
To measure cardiovascular fitness, a stress test on either an upright cycle ergometer (Ergoselect 200P, Germany), or a treadmill (same modality pre- and post-training) was performed depending on patient balance and comfort.
Secondary Outcomes
- Cognition(Baseline and 3 months (non-intervention period), after 6 months of cardiac rehabilitation participation)
- Center for Epidemiologic Studies Depression Scale (CES-D).(Baseline and 3 months (non-intervention period), after 6 months of cardiac rehabilitation participation)
Investigators
Dina Brooks
Professor
Toronto Rehabilitation Institute