ACTRN12611000601932
Terminated
未知
A prospective comparison of corneal cross linking treatment parameters and outcomes for juvenile onset early keratoconus
Dr James MC Alister0 sites102 target enrollmentJune 10, 2011
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Dr James MC Alister
- Enrollment
- 102
- Status
- Terminated
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Early Keratoconus must be evidenced by one or more of the following Pentacam derived topographic abnormalities in the study eye
- •1\. Corneal shape factor indicative of keratoconus on Pentacam assessment
- •Abnormal Enhanced Ectasia Display flags abnormalities based on regression analysis of findings compared to normality indices for
- •(A) Corneal thickness spatial profile (CTSP)
- •(B) Percentage thickness increase (PTI)
- •(C) Deviation parameters (D)
- •2\. Thinnest pachymetry of less than 480microm
- •3\. Kmax of greater than 48 D
- •4\. Posterior corneal elevation of greater than 25 microm on Pentacam analysis
- •and be associated with patient reported history, topographic or refraction data which indicates one of the following changes notes in less than a 12 month period of follow up.
Exclusion Criteria
- •Exclusion criteria
- •Eyes will not be eligible to be recruited into the trial if anyone or more of the following apply:
- •1\. Patient age is 18 years or older
- •2\. There is a history of previous corneal surgery.
- •3\. Corneal pachymetry of less than 340microm (thinnest point measured by Pentacam topographer.
- •4\. Insufficient ability to comply with full testing involved in the study
- •5\.The presence of visually significant corneal stromal scarring.
- •6\. The existence of other corneal pathology.
- •7\. A history of herpetic keratitis, chemical injury, or delayed epithelial healing.
- •8\. Recurrent corneal erosion syndrome.
Outcomes
Primary Outcomes
Not specified
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