Effect of Transversus Abdominis Plane Block Combined With Dexmedetomidine Infusion on the Prognosis in Elderly Patients Undergoing Abdominal Surgery

Not Applicable

• Conditions: Aged; Colorectal Neoplasms
• Interventions: Procedure: Transversus abdominis plane block using ropivacaine; Procedure: Transversus abdominis plane block using saline; Drug: Saline; Drug: Dexmedetomidine

• Registration Number: NCT04516174
• Lead Sponsor: Beijing Tiantan Hospital

Brief Summary

To compare the prognosis of elderly patients undergoing radical resection of colorectal cancer treated with general anesthesia and general anesthesia combined with transversus abdominis plane block and continuous infusion of dexmedetomidine. The incidence of postoperative delirium, postoperative acute pain moderately to severely and poor postoperative recovery were composite endpoints to determine the prognosis of patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-08
• Study First Submitted: 2020-08-11
• Study First Submitted QC: 2020-08-17
• Last Update Submitted: 2020-08-17
• Study First Posted: 2020-08-18
• Last Update Posted: 2020-08-18
• Study Start: 2020-09-01
• Primary Completion: 2022-12-31
• Study Completion: 2023-09-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

• Aged 65-80 years,regardless of gender
• American Society of Anesthesiologists physical status I-III
• Undergoing elective radical resection of colorectal cancer
• Sign informed consent

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Exclusion Criteria

• Could not cooperate to complete the pain VAS evaluation
• Could not cooperate to complete the cognitive function assessment

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Saline	Patients in control group will receive the bilateral transversus abdominis plane block with saline 20ml each side before anesthesia and don't receive the infusion of dexmedetomidine during operation.
Dex+TAPB group	Transversus abdominis plane block using ropivacaine	Patients in Dex+TAPB group will receive the bilateral transversus abdominis plane block with 0.25% ropivacaine 20ml each side before anesthesia and combined with continuous infusion of dexmedetomidine during operation.
Control group	Transversus abdominis plane block using saline	Patients in control group will receive the bilateral transversus abdominis plane block with saline 20ml each side before anesthesia and don't receive the infusion of dexmedetomidine during operation.
Dex+TAPB group	Dexmedetomidine	Patients in Dex+TAPB group will receive the bilateral transversus abdominis plane block with 0.25% ropivacaine 20ml each side before anesthesia and combined with continuous infusion of dexmedetomidine during operation.

Primary Outcome Measures

Name	Time	Method
The prognosis of aged patients	Postoperative 72 hours	The incidence of postoperative delirium, postoperative acute pain moderately to severely and poor postoperative recovery were composite endpoints to determine the prognosis of patients.

Trial Locations

Locations (1)

Beijing Tian Tan Hospital; 🇨🇳 Beijing, China