Effect of Transversus Abdominis Plane Block Combined With Dexmedetomidine Infusion on the Prognosis in Elderly Patients Undergoing Abdominal Surgery
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- The prognosis of aged patients
研究概览
简要总结
To compare the prognosis of elderly patients undergoing radical resection of colorectal cancer treated with general anesthesia and general anesthesia combined with transversus abdominis plane block and continuous infusion of dexmedetomidine. The incidence of postoperative delirium, postoperative acute pain moderately to severely and poor postoperative recovery were composite endpoints to determine the prognosis of patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 65-80 years,regardless of gender
- •American Society of Anesthesiologists physical status I-III
- •Undergoing elective radical resection of colorectal cancer
- •Sign informed consent
排除标准
- •Could not cooperate to complete the pain VAS evaluation
- •Could not cooperate to complete the cognitive function assessment
研究组 & 干预措施
Control group
Patients in control group will receive the bilateral transversus abdominis plane block with saline 20ml each side before anesthesia and don't receive the infusion of dexmedetomidine during operation.
干预措施: Transversus abdominis plane block using saline (Procedure)
Control group
Patients in control group will receive the bilateral transversus abdominis plane block with saline 20ml each side before anesthesia and don't receive the infusion of dexmedetomidine during operation.
干预措施: Saline (Drug)
Dex+TAPB group
Patients in Dex+TAPB group will receive the bilateral transversus abdominis plane block with 0.25% ropivacaine 20ml each side before anesthesia and combined with continuous infusion of dexmedetomidine during operation.
干预措施: Transversus abdominis plane block using ropivacaine (Procedure)
Dex+TAPB group
Patients in Dex+TAPB group will receive the bilateral transversus abdominis plane block with 0.25% ropivacaine 20ml each side before anesthesia and combined with continuous infusion of dexmedetomidine during operation.
干预措施: Dexmedetomidine (Drug)
结局指标
主要结局
The prognosis of aged patients
时间窗: Postoperative 72 hours
The incidence of postoperative delirium, postoperative acute pain moderately to severely and poor postoperative recovery were composite endpoints to determine the prognosis of patients.
次要结局
未报告次要终点
研究者
Yuming Peng
Vice Professor
Beijing Tiantan Hospital