Nomograms to Precisely Predict Conditional Risk of Recurrence for Patients With Laryngeal Cancer

• Conditions: Recurrent Laryngeal Cancer
• Interventions: Other: Recurrence laryngeal cancer

• Registration Number: NCT03595410
• Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Brief Summary

Advanced laryngeal squamous cell carcinoma (SCC) remains a highly morbid and fatal disease despite aggressive interventions. Mortality is high in this cohort: laryngeal cancer affects over 13 000 patients in the United States, with over 3500 deaths annually.The results of the Veterans Affairs Cooperative Studies Program Laryngeal Cancer Trial and subsequent studies demonstrated similar overall survival (OS) rates for organ preservation protocols involving radiotherapy (RT) or chemoradiotherapy (CRT) when compared to surgery, with the benefit of preserving the larynx in a large majority of patients. As such, the use of RT or CRT has become the predominant initial intervention for patients with laryngeal SCC.6 However, the prognosis of recurrent and persistent laryngeal SCC is particularly dire.In this study, we sought to identify preoperative predictors of survival for patients with recurrent or persistent laryngeal SCC in order to set patient expectations and address modifiable risk factors. Identification of predictors of survival may also identify patients who could benefit from novel therapeutic agents in a neo/adjuvant fashion. Herein,we examine a cohort of patients with recurrent or persistent laryngeal SCC after definitive RT/CRT who has undergone total laryngectomy in order to identify potential preoperative predictors of clinical outcomes.

Detailed Description

Demographic, clinical, and survival data were abstracted. Death was verified via medical records and the social security death index. Primary outcome measures were OS (time from salvage laryngectomy to death from any cause), disease-specific survival (DSS; time from salvage laryngectomy to death from recurrent/persistent laryngeal SCC), and DFS (time from salvage laryngectomy to laryngeal SCC recurrence)

Study Timeline

• Study Start: 2017-01-01
• Status Verified: 2018-07
• Study First Submitted: 2018-07-13
• Study First Submitted QC: 2018-07-13
• Last Update Submitted: 2018-07-13
• Study First Posted: 2018-07-23
• Last Update Posted: 2018-07-23
• Primary Completion: 2020-01-01
• Study Completion: 2020-01-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

patients with a diagnosis of laryngeal squamous cell carcinoma

Exclusion Criteria

multiple primarry malignant neo-plasms

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
No recurrence laryngeal cancer	Recurrence laryngeal cancer	-
Recurrence laryngeal cancer	Recurrence laryngeal cancer	-

Primary Outcome Measures

Name	Time	Method
Overall survival	Follow up 5 years	time from salvage laryngectomy to death from any cause

Trial Locations

Locations (1)

Genglong Liu; 🇨🇳 Guangzhou, Guangdong, China