NCT00046709终止1 期
Marijuana in Combination With Opioids for Cancer Pain: A Pilot Study
Center for Medicinal Cannabis Research2 个研究点 分布在 1 个国家目标入组 16 人开始时间: 2002年9月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 终止
- 发起方
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Change in level of cancer pain as recorded on a 100mm Visual Analog Scale.
研究概览
简要总结
To find out if it is safe and effective to use smoked marijuana in combination with opioids to treat cancer pain. The study will evaluate whether smoked marijuana, when used with opioids, will have an effect on pain relief, and to see if marijuana reduces the side effects of opioids, which include nausea and/or vomiting.
详细描述
To take part in this study, you must have ongoing cancer pain which is currently being treated with opioids. If you meet all the eligibility criteria you will be admitted to the General Clinical Research Center at San Francisco General Hospital for 9 days. The treatment consists of smoking one marijuana cigarette 3 times a day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Have ongoing cancer pain
- •Be diagnosed with cancer and have at least a six month survival.
- •Be on a stable dose of opioid medication for at least 2 weeks before enrollment.
- •Have smoked marijuana on at least 6 occasions in their lifetime prior to enrollment.
排除标准
- •You must not:
- •Start chemotherapy, radiation or biphosphonates during the study, or have received any new intervention with any such agents within the past 4 weeks.
- •Currently be using smoked tobacco products.
- •Currently be in methadone treatment.
- •Have smoked marijuana within 30 days of enrollment.
- •Be diagnosed with diabetes mellitus.
- •Have severe heart disease, uncontrolled hypertension, or lung disease.
- •Currently be receiving treatment with corticosteroids.
- •Be pregnant or breastfeeding.
结局指标
主要结局
Change in level of cancer pain as recorded on a 100mm Visual Analog Scale.
次要结局
- Change in level of experimentally induced pain on a 100mm Visual Analog Scale.
- Change in nausea and emesis in participants exhibiting these symptoms.
- Change in disposition kinetics of opioid analgesics.
研究者
研究点 (2)
Loading locations...
相似试验
已完成
1 期
Opioid and Cannabinoid Pharmacokinetic InteractionsPainNCT00308555University of California, San Francisco24
已完成
1 期
Marijuana in Combination With Opioids in Palliative and Hospice PatientsPainNCT03233633The Connecticut Hospice Inc.66
已完成
1 期
Opioid and Cannabinoid InteractionsMarijuana UsageOpioid UseNCT03705559Shanna Babalonis, PhD10
已完成
不适用
Cannabis Use in Cancer PatientsSolid Tumor, AdultNCT03617692University of Colorado, Denver27
招募中
不适用
IMmunotherapy: Prospective Assessment of Cannabis Treatment in CancerCancerNCT06206941State University of New York at Buffalo450