Evaluation of reflexology as an adjunctive therapy in children with refractory Childhood Epilepsy including West Syndrome

All India Institute of Medical Sciences0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年5月27日

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•1. Age: 6 months to 12 years
•2. Presence of seizures persisting daily or more than 7 per week despite the adequate trial of at least three tolerated and appropriately chosen and used anti-epileptic drugs including one newer antiepileptic drug (either alone or in combination). In case of infantile spasms, epileptic spasms with the onset before 2 years of age, with or without electroencephalographic evidence of hypsarrhythmia or its variants, persisting for more than 3 weeks, at least 7 cluster per week, despite treatment with at least 2 appropriate AEDs, and any one of the following; corticosteroids or vigabatrin.
•3. Residents of Delhi/National capital region.

•1.Known or suspected inborn error of metabolism, as evidenced by:
•Clinical suspicion of metabolic disorder as evidenced by 2 or more of the following- a history of parental consanguinity, prior affected siblings, unexplained vomiting, intermittent worsening of symptoms, recurrent episodes of lethargy, altered sensorium, or ataxia, hepatosplenomegaly on examination
•And/ or 2 or more of the following biochemical abnormalities
•High blood ammonia ( >80mmol/L), High arterial lactate ( >2 mmol/L), metabolic acidosis (pH <7.2), hypoglycemia (blood sugar <40 mg/dl), abnormal urinary aminoacidogram, presence of reducing sugars or ketones in urine, and positive results on urine neurometabolic screening tests.
•2.Motivational or psychosocial issues in the family which would preclude compliance.
•3.Systemic illness- chronic hepatic, renal or pulmonary disease.

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