An exploratory study for development of neurophysiological indicators for prediction and evaluation of effectiveness of serotonin reuptake inhibitor fluvoxamine in patients with major depressive disorder - An exploratory study for development of neurophysiological indicators for effectiveness of fluvoxamine in major depression

Department of Neuropsychiatry, The University of Tokyo Hospital0 sites20 target enrollmentAugust 4, 2008

ConditionsMajor depressive disorder

Overview

Phase: N/A
Intervention: Not specified
Conditions: Major depressive disorder
Sponsor: Department of Neuropsychiatry, The University of Tokyo Hospital
Enrollment: 20
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

No summary available.

Registry

who.int

Start Date

August 4, 2008

End Date

August 1, 2010

Last Updated

2 years ago

Study Type

Interventional

Sex

All

Investigators

Sponsor

Department of Neuropsychiatry, The University of Tokyo Hospital

Eligibility Criteria

Inclusion Criteria

Not provided

Exclusion Criteria

•1\)No major cognitive deficits 2\)Subjects taking fluvoxamine therapy 3\)Subjects who cannot discontinue therapies listed below from 7 days prior to the trial start to the end point. 1\.Thioridazine Hydrochloride, pimozide 2\. Tizanidine hydrochloride 3\.MAO inhibitors, Selegiline hydrochloride ( 14 days before starting the trial) 4\.Cisapride 5\.Any drugs under development 6\.Any anticonvulsants 7\.Any antipsychotic drugs 8\.Antidepressants excluding Fluvoxamine 9\.Lithium Carbonate 10\.Chinese medicine effective on psychotic symptoms 11\.Electroconvulsive therapy 12\.Other physical treatments 4\) Subjects with current DSM\-IV personality disorder or mental retardation 5\)Pregnant or lactating women 6\)Subjects with severe hepatic dysfunction (AST\>100 or ALT\>100\) 7\)Subjects with severe renal dysfunction (BUN\>25 or Cre\>2\.0\) 8\) Subjects with current or past history of convulsion 9\)Subjects with current or past history of serious suicidal ideation or attempt (HAM\-D item No.11 score \> 3\) 10\)Subjects with past history of manic state or bipolar disorder 11\)Subjects with brain organic disease, including current or past history of cerebrovascular disease and other related disorders 12\)Past history of electric convulsive therapy 13\)Subjects with cardiac failure which requires clinical treatment 14\)Subjects with hemophilic disease or hemophilic factor which requires clinical treatment 15\)Subjects with thyroidal dysfunction which requires clinical treatment 16\)Ungiven notification of the disease name 17\)Patient whom examination doctor judged improper as a trial subject