Collagen Injections for the Treatment of Acne Scars and Wrinkles
Phase 1
Terminated
- Conditions
- Acne ScarsWrinkles
- Interventions
- Procedure: VehicleDrug: Fibroblast Treatment
- Registration Number
- NCT01704209
- Lead Sponsor
- Northwestern University
- Brief Summary
The purpose of this study is to find out if autologous (your own) fibroblast injections are effective for the treatment of acne scars and wrinkles.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 4
Inclusion Criteria
- Age 18 or over
- Bilateral acne scars or have moderate to severe wrinkles
- Subjects in good health
- Subjects has the willingness and the ability to understand and provide informed consent for the use of their tissue and communicate with the investigator
Exclusion Criteria
- Under 18 years of age
- Pregnancy or lactation
- recent Accutane use in the past 6 months
- prone to hypertrophic and keloidal scarring
- have excessively redundant skin in the treatment area or wrinkles longer than 20 cm total
- have a history of autoimmune disorders, organ transplantation, cancer not in remission, active or chronic skin disease
- have a history of basal-cell carcinoma
- have previously received autologous fibroblast treatment
- have undergone any confounding therapy in the lower two-thirds of the face within 1 year or any investigational treatment within 30 days.
- have an allergy to collagen, bovine products, local anesthetics, gentamicin, or amphotericin B
- subjects who are unable to understand the protocol or to give informed consent
- subjects with mental illness
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Vehicle Vehicle The vehicle will be injected randomly to the other side of the face. Fibroblast Treatment Fibroblast Treatment The fibroblast treatment will be randomly injected into one side of the face.
- Primary Outcome Measures
Name Time Method Change from baseline of rater's comparisons at 6 months Basline and 6 months
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms drive autologous fibroblast injection efficacy in NCT01704209 for acne scars and wrinkles?
How does autologous fibroblast therapy compare to hyaluronic acid fillers in treating static crow's feet and lip lines?
Which biomarkers correlate with response to fibroblast-based treatments in acne scar and wrinkle clinical trials?
What adverse events are associated with autologous fibroblast injections in Phase 1 trials for dermal rejuvenation?
Are there combination therapies involving autologous fibroblasts and botulinum toxin for horizontal neck lines and forehead wrinkles?
Trial Locations
- Locations (1)
Northwestern University Feinberg School of Medicine, Department of Dermatology
🇺🇸Chicago, Illinois, United States
Northwestern University Feinberg School of Medicine, Department of Dermatology🇺🇸Chicago, Illinois, United States