The European Prospective Investigation Into Cancer in Norfolk Prospective Population Study

Active, not recruiting

• Conditions: Neoplasms; Cardiovascular Diseases; Death

• Registration Number: NCT03424668
• Lead Sponsor: University of Cambridge

Brief Summary

The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease.

Detailed Description

The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease. Detailed data on sociodemographic, lifestyle, medical and family history were collected and a biological sample bank including urine and blood samples established. Participants have been followed up through repeat examinations, mailed questionnaires as well as through record linkage with routine health records including death certification by cause, cancer registration and hospital admissions by cause till present.

Study Timeline

• Study Start: 1992-01-01
• Study First Submitted: 2018-01-25
• Study First Submitted QC: 2018-01-31
• Study First Posted: 2018-02-07
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-15
• Last Update Posted: 2019-04-16
• Primary Completion: 2040-12-31
• Study Completion: 2040-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 25639

Inclusion Criteria

• Willing to participate
• On general practice age sex registers in Norfolk, United Kingdom in 1993-1997

Exclusion Criteria

• Not willing to participate in study
• terminal illness

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
neoplasms	Through 25 years	cancer incidence

Secondary Outcome Measures

Name	Time	Method
cardiovascular diseases	through 25 years	incidence of cardiovascular diseases
death	through 25 years	total mortality by cause