Management of Acute Heart Failure: Contribution of Ultrasound Daily "in Bed Patient" Adjustment on Therapy With Impact Measure on re Hospital Rate During 30 Days

Not Applicable

Completed

• Conditions: Heart Failure
• Interventions: Procedure: Transmitral flow estimation

• Registration Number: NCT02892227
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

Our hypothesis: a daily bedside echocardiographic assessment, protocolized, simple and reproducible estimation of filling pressures with an evaluation of mitral inflow and the inferior vena cava, allow a more reliable estimate of the true blood volume of the patient and thus lead to a therapeutic adjustment more suitable.

This therapeutic adjustment closer to patient's needs would impact fewer readmissions at 30 days and mortality, less alteration of biological parameters myocardial, kidney and liver.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-08-26
• Study First Submitted QC: 2016-09-01
• Study First Posted: 2016-09-08
• Study Start: 2016-11-15
• Status Verified: 2018-12
• Primary Completion: 2019-01-07
• Study Completion: 2019-06-22
• Last Update Submitted: 2019-08-05
• Last Update Posted: 2019-08-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

The patient or his representative must be given free and informed consent and signed consent.

• The patient must be affiliated or beneficiary of a health insurance plan.
• The patient is available for a follow-up 6 months.
• The patient is of age or older (>) 18.
• Patients hospitalized for acute heart failure who received at least 40mg of furosemide IV.
• Patient with impaired LVEF <50%.
• Patient with Nt-proBNP values> 1200pg / ml.

Exclusion Criteria

• The subject takes part in another study.

  • The subject is exclusion period determined by a previous study.
  • The subject is under judicial protection.
  • The subject or his representative refuses to sign the consent.
  • It is not possible to give the subject or his representative informed information.

Non-inclusion criteria for those diseases or conditions associated (s) interfere (s):

• The patient is pregnant or is breastfeeding.
• The patient is already included in a surveillance program (PRADO, OSICAT).
• Patient with a mechanical or biological mitral prosthesis.
• History of mitral stenosis.
• severe valvular surgery with maturity in months (<30 days).
• chronic renal impairment on dialysis.
• High grade AV block (AVB and BAV3 2/1).
• Hypertrophic cardiomyopathy.
• Cardiogenic shock.
• Contraindications to furosemide.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
JET ECHO	Transmitral flow estimation	Transmitral flow estimation

Primary Outcome Measures

Name	Time	Method
rehospitalization	30 days

Secondary Outcome Measures

Name	Time	Method
worsening heart failure	during hospitalization
average length of stay	during hospitalization
alteration of biological parameters myocardial, kidney and liver	Hospital discharge +7 days, Hospital discharge +30 days
mortality	6 months

Trial Locations

Locations (2)

CHU Arnaud de Villeneuve; 🇫🇷 Montpellier, France

CHU Nimes; 🇫🇷 Nîmes, France