Effect of photodynamic therapy on inflammatory biomarkers and clinical parameters in moderate to severe chronic periodontitis
Not Applicable
- Conditions
- Chronic periodontitis.Chronic periodontitis
- Registration Number
- IRCT2012121611770N1
- Lead Sponsor
- Dental and Periodontal Research Center of the Tabriz University of Medical Sciences (Primary sponsor
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 24
Inclusion Criteria
Moderate to severe Chronic periodontitis; existence of a minimum of 12 teeth in oral cavity with at least three natural teeth in four sites per quadrant; = 3mm of attachment loss in minimum of 30 percent of teeth; presence of at least one site with pocket depth of = 4mm with bleeding on probing in per quadrant. Exclusion criteria: The ingestion of systemic antibiotics within the last one year, non-surgical periodontal treatment within the last 6 months; smoking; uncontrolled Diabetes; liver disease; malignancy; radiotherapy; pregnancy; females on estrogen therapy; allergic reactions to Toluidine blue.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Probing depth. Timepoint: after 3 month. Method of measurement: Periodontal probe.
- Secondary Outcome Measures
Name Time Method Interleukin-1ß level in gingival crevicular fluid. Timepoint: After 3 month. Method of measurement: ELIZA Kit.;TNF-alpha level in gingival crevicular fluid. Timepoint: After 3 month. Method of measurement: ELIZA Kit.;MMP-9 Level in gingival crevicular fluid. Timepoint: After 3 month. Method of measurement: ELIZA Kit.;MMP-8 Level in gingival crevicular fluid. Timepoint: After 3 month. Method of measurement: ELIZA Kit.