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Zenith® Dissection Clinical Trial

Not Applicable
Completed
Conditions
Aortic Dissection
Interventions
Device: Endovascular Treatment (Zenith)
Registration Number
NCT01568320
Lead Sponsor
Cook Research Incorporated
Brief Summary

The Zenith® Dissection Clinical Trial is a clinical trial approved by US FDA to study the safety and effectiveness of the Zenith® Dissection Endovascular System in the treatment of acute, complicate Type B aortic dissection.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
73
Inclusion Criteria

Not provided

Exclusion Criteria
  1. Age < 18 years;
  2. Other medical condition (e.g., cancer, congestive heart failure) that may cause the patient to be non-compliant with the Clinical Investigation Plan, confound the results, or is associated with limited life expectancy (i.e., less than 2 years);
  3. Pregnant, breast-feeding, or planning on becoming pregnant within 60 months;
  4. Unwilling or unable to comply with the follow-up schedule;
  5. Inability or refusal to give informed consent;
  6. Simultaneously participating in another investigative device or drug study. (The patient must have completed the primary endpoint of any previous study at least 30 days prior to enrollment in this study.);
  7. Additional medical restrictions as specified in the Clinical Investigation Plan; or
  8. Additional anatomical restrictions as specified in the Clinical Investigation Plan.

Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Arm && Interventions
GroupInterventionDescription
EndovascularEndovascular Treatment (Zenith)Endovascular Treatment (Zenith)
Primary Outcome Measures
NameTimeMethod
Survival Rate at 30 Days30 days

Primary effectiveness endpoint is freedom from all cause mortality at 30 days

Number of Participants With Freedom From Major Adverse Events30 days

Primary safety : Major adverse events include: myocardial infarction, chronic renal insufficiency/chronic renal failure requiring dialysis, bowel ischemia, stroke, paraplegia or paraparesis, and prolonged ventilator support

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (24)

Cedars-Sinai Medical Center

🇺🇸

Los Angeles, California, United States

University of Massachusetts

🇺🇸

Worcester, Massachusetts, United States

Hackensack University Medical Center

🇺🇸

Hackensack, New Jersey, United States

Hospital of the University of Pennsylvania

🇺🇸

Philadelphia, Pennsylvania, United States

Allegheny General Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

University of Pittsburgh Medical Center

🇺🇸

Pittsburgh, Pennsylvania, United States

University of Florida

🇺🇸

Gainesville, Florida, United States

Indiana Heart Hospital

🇺🇸

Indianapolis, Indiana, United States

Massachusetts General Hospital

🇺🇸

Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center

🇺🇸

Boston, Massachusetts, United States

Barnes-Jewish Hospital

🇺🇸

Saint Louis, Missouri, United States

University of Michigan Hospital

🇺🇸

Ann Arbor, Michigan, United States

Cooper University Hospital

🇺🇸

Camden, New Jersey, United States

New York University Hospital

🇺🇸

New York, New York, United States

The Christ Hospital

🇺🇸

Cincinnati, Ohio, United States

Scott and White Hospital

🇺🇸

Temple, Texas, United States

The Methodist Hospital

🇺🇸

Houston, Texas, United States

University of Virginia Medical Center

🇺🇸

Charlottesville, Virginia, United States

Sentara Vascular Specialists

🇺🇸

Norfolk, Virginia, United States

University of Washington-Harborview Medical Center

🇺🇸

Seattle, Washington, United States

Jikei University School of Medicine

🇯🇵

Tokyo, Japan

Dartmouth Hitchcock Medical Center

🇺🇸

Lebanon, New Hampshire, United States

Duke University Medical Center

🇺🇸

Durham, North Carolina, United States

University of South Florida

🇺🇸

Tampa, Florida, United States

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