Effects of physiological induced changes in afterload of the left ventricle on the strain-volume loop

Completed

• Conditions: cardiac function; 10019280

• Registration Number: NL-OMON45478
• Lead Sponsor: Fysiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2019-04-18
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 35

Inclusion Criteria

Age (between 18 and 30 or above 60)
voluntary participation

Exclusion Criteria

History of cardiovascular diseases (coronary disease, hypertension, collapse, cardiac failure, peripheral vascular disease)
Diabetes mellitus
Use of medication that influences the cardiovascular system
Contraindication to use nitroglycerin (hypersensitivity or usage of medication that interacts wit nitroglycerin

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter will be the slope of the systolic strain-volume<br /><br>relation (Sslope)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary parameters will be the early systolic strain (*_ES), peak strain<br /><br>(peak *) and the dissociation between the systolic and diastolic strain-volume<br /><br>relation during early diastole (UNCOUP_ED) and late diastole (UNCOUP_LD). </p><br>