Neurophysiological Marker of ADHD in Children
- Conditions
- Attention Deficit Hyperactivity DisorderPsychiatric DiagnosisDiagnosis, Psychiatric
- Interventions
- Diagnostic Test: electroencephalography absolute delta powerDiagnostic Test: electroencephalography relative delta powerDiagnostic Test: electroencephalography absolute theta powerDiagnostic Test: electroencephalography relative theta powerDiagnostic Test: electroencephalography absolute slow alpha powerDiagnostic Test: electroencephalography relative slow alpha powerDiagnostic Test: electroencephalography absolute fast alpha powerDiagnostic Test: electroencephalography relative fast alpha powerDiagnostic Test: electroencephalography absolute beta powerDiagnostic Test: electroencephalography relative beta powerDiagnostic Test: Korean ADHD rating scaleDiagnostic Test: Korean Version of Diagnostic Interview Schedule for Children Version IV
- Registration Number
- NCT04467658
- Lead Sponsor
- Daegu Catholic University Medical Center
- Brief Summary
This study investigated quantitative electroencephalography (QEEG) subtypes as auxiliary tools to assess Attention Deficit Hyperactivity Disorder (ADHD). Patient assessed using the Korean version of the Diagnostic Interview Schedule for Children Version IV and were assigned to one of three groups: ADHD, ADHD-Not Otherwise specified (NOS), and Neurotypical (NT). The investigators measure absolute and relative EEG power in 19 channels and conducted an auditory continuous performance test. The investigators analyzed QEEG according to the frequency range: delta (1-4 Hz), theta (4-8 Hz), slow alpha (8-10 Hz), fast alpha (10-13.5 Hz), and beta (13.5-30 Hz). The subjects were then grouped by Ward's method of cluster analysis using the squared Euclidian distance to measure dissimilarities.
- Detailed Description
Participants between 7 and 12 years of age diagnosed with ADHD according to the DSM-5 criteria were included in the study. The ADHD diagnosis was based on a Korean version of the Diagnostic Interview Schedule for Children Version IV (DISC-IV), which is a structured interview tool, and these diagnoses were confirmed by multiple child and adolescent psychiatrists. If participants did not meet the ADHD diagnostic criteria of DSM-IV and DISC-IV, they were assigned to the Neurotypical (NT) group. Based on the results of the DISC-IV test, participants were assigned to the ADHD or Non-Other Specified (NOS) group. Patients who met the diagnostic criteria of ADHD in DSM-IV, but whose score did not exceed six, and had a score of more than three in the attention deficit or hyperactivity/impactivity scale of DISC-IV were included in the NOS group. Children with a history of brain damage, neurological disorders, genetic disorders, substance dependence, epilepsy, or any other mental disorder were excluded from participation. Children with an IQ of 70 or lower according to the Korean-Wechsler Intelligence Scale for Children (Fourth Edition) or who were receiving drug treatment were also excluded from this study. The EEG recordings were performed using a SynAmps2 direct-current (DC) amplifier and a 10-20 layout 64-channel Quick-Cap electrode-placement system (Neuroscan Inc., NC, USA). The EEG data were digitally recorded from 19 gold cup electrodes placed according to the international 10-20 system. The impedances were maintained below 5 kΩ, and the sampling rate was 1000 Hz. The investigators use the linked mastoid reference and two additional bipolar electrodes to measure horizontal and vertical eye movements. During the recording, each participant laid in a dimly lit, electrically shielded, sound-attenuated room. Resting EEG recordings were recorded after three minutes with the participants' eyes closed.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 140
- Participants between 7 and 12 years of age diagnosed with ADHD according to the DSM-5 criteria were included in the study
- Children with a history of brain damage, neurological disorders, genetic disorders, substance dependence, epilepsy, or any other mental disorder were excluded from participation.
- Children with an IQ of 70 or lower according to the Korean-Wechsler Intelligence Scale for Children (Fourth Edition) or who were receiving drug treatment were also excluded from this study
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description ADHD electroencephalography relative theta power - NT NeuroTypical electroencephalography absolute delta power - NT NeuroTypical electroencephalography relative theta power - ADHD NOS electroencephalography relative delta power - ADHD electroencephalography absolute slow alpha power - NT NeuroTypical Korean Version of Diagnostic Interview Schedule for Children Version IV - ADHD NOS electroencephalography relative theta power - ADHD NOS electroencephalography absolute fast alpha power - ADHD electroencephalography relative slow alpha power - ADHD electroencephalography relative fast alpha power - ADHD electroencephalography absolute beta power - NT NeuroTypical electroencephalography relative delta power - ADHD electroencephalography absolute delta power - ADHD electroencephalography absolute theta power - ADHD electroencephalography absolute fast alpha power - ADHD electroencephalography relative beta power - ADHD electroencephalography relative delta power - ADHD Korean ADHD rating scale - ADHD Korean Version of Diagnostic Interview Schedule for Children Version IV - NT NeuroTypical electroencephalography absolute theta power - NT NeuroTypical electroencephalography absolute beta power - ADHD NOS electroencephalography absolute delta power - ADHD NOS Korean Version of Diagnostic Interview Schedule for Children Version IV - NT NeuroTypical electroencephalography absolute slow alpha power - NT NeuroTypical electroencephalography relative slow alpha power - NT NeuroTypical electroencephalography absolute fast alpha power - NT NeuroTypical electroencephalography relative fast alpha power - NT NeuroTypical electroencephalography relative beta power - ADHD NOS electroencephalography relative slow alpha power - NT NeuroTypical Korean ADHD rating scale - ADHD NOS electroencephalography absolute slow alpha power - ADHD NOS Korean ADHD rating scale - ADHD NOS electroencephalography absolute theta power - ADHD NOS electroencephalography absolute beta power - ADHD NOS electroencephalography relative fast alpha power - ADHD NOS electroencephalography relative beta power -
- Primary Outcome Measures
Name Time Method QEEG topographical plots of the results of the statistical comparisons to normative values (z-scores) using Neuroguide software through study completion, an average of 1 year The investigators measures QEEG on first outpatient clinic and conduct topography for mapping
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Daegu Catholic University Medical Center
🇰🇷Daegu, Nam-gu, Korea, Republic of