The Association With Peptic Ulcer Disease and Hepatic Vein Pressure Gradient

Completed

• Conditions: Chronic Liver Disease; Cirrhosis

• Registration Number: NCT01944878
• Lead Sponsor: Chuncheon Sacred Heart Hospital

Brief Summary

The aim of this study is to assess the role of portal hypertension of peptic ulcer disease in liver cirrhosis and chronic hepatitis.

Detailed Description

Retrospective case-control study

* Investigators will analyze the medical records of hepatic vein pressure gradient (HVPG) and esophagogastroduodenoscopy (EGD) cases who had liver cirrhosis (LC) or chronic hepatitis in a single tertiary hospital (Chuncheon Sacred Heart hospital, Korea) within 2008\~2012.

* Portal hypertension is assessed using HVPG measurement via transjugular approach.

* Peptic ulcer is evaluated through EGD within 3 months of HVPG measurement

* The association of Peptic ulcer with LC, chronic hepatitis and total population (LC or chronic hepatitis) will be assessed by univariate and multivariate analysis

* There is no specific time frame, because this study is retrospective observational study, however EGD data is enrolled if it was done within 3 month from HVPG measurement.

Study Timeline

• Study Start: 2013-05
• Primary Completion: 2013-08
• Study Completion: 2013-08
• Study First Submitted: 2013-09-06
• Study First Submitted QC: 2013-09-17
• Study First Posted: 2013-09-18
• Results First Submitted: 2014-01-23
• Status Verified: 2014-07
• Results First Submitted QC: 2014-07-22
• Last Update Submitted: 2014-07-22
• Results First Posted: 2014-07-24
• Last Update Posted: 2014-07-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 455

Inclusion Criteria

• The patients who underwent hepatic vein pressure gradient (HVPG) measurement and esophagogastroduodenoscopy (EGD) and also had LC or chronic hepatitis

Exclusion Criteria

• The patients who have missing or incomplete HVPG or EGD data
• The patients who underwent gastrectomy
• The patients who have systemic malignancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The Association of HVPG and PUD in Patients With Liver Cirrhosis	Retrospective case-control study (from 2009 to 2012, up to 3 years)	The association of hepatic vein pressure gradient that reflects portal hypertension and peptic ulcer disease in patients with liver cirrhosis was assessed statistically.; (NO specific time frame, only confined to 2009 to 2012, when the HVPG measurement was done). The Mann-Whitney test was used to evaluate the association between PUD or not and HVPG degree, by SPSS software.

Secondary Outcome Measures

Name	Time	Method
The Association Between PUD and HVPG in Patients With Chronic Hepatitis	Retrospective case-control study (from 2009 to 2012, up to 3 years)

Trial Locations

Locations (1)

Chuncheon Sacred Heart hospital; 🇰🇷 Chuncheon, Gangwon-do, Korea, Republic of