Diseases of the lipid metabolism and the structure of the retina
Recruiting
- Conditions
- Age-related macular degeneration, hereditary mutations in lipid metabolism
- Registration Number
- NL-OMON25132
- Lead Sponsor
- Amsterdam University Medical Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
At least 18 years of age.
- Have one or more mutations in lipid metabolism
Exclusion Criteria
- Age under 18 years
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Presence or absence of retinal drusen
- Secondary Outcome Measures
Name Time Method Morphology of drusen and other signs of AMD, optical coherence tomography (+OCT angiography) characteristics, visual acuity, mid-peripheral and peripheral retinal changes
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link hereditary lipid metabolism defects to retinal phenotypes in age-related macular degeneration?
Are there specific lipid metabolism biomarkers that correlate with retinal structural changes in patients with hereditary lipid disorders?
How do observational studies of lipid metabolism mutations inform novel therapeutic targets for age-related macular degeneration?
What comparative insights exist between retinal lipid metabolism dysfunction and standard-of-care treatment outcomes in AMD patients?
What adverse events are associated with lipid metabolism modulation in retinal disease trials and how are they managed?