Identification of Novel Periodontal Disease Biomarkers Using microRNA Expression in Saliva
试验速览
- 阶段
- 不适用
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Expression level of MicroRNAs using Microarray
研究概览
简要总结
The purpose of the present study is to identify the novel periodontal disease biomarkers using differentially expressed microRNA in the saliva. The severity of chronic periodontal diseases and the time of pre- and post-treatment are major classification criteria. The obtained data will secure the foundation for the development of a new non-invasive diagnostic methods for early diagnosis & prognosis prediction of periodontal disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •A. Severe Periodontal Disease
- •Patients with chronic severe periodontitis
- •Primary treatment of periodontal scaling, subgingival curettage is required, and the general progress of the protocol agreed with the basic periodontal therapy patients.
- •subjects agreed collecting saliva and gingival crevicular fluid and physicochemical tests and genetic testing
- •A. Moderate Periodontal Disease
- •Patients with chronic moderate periodontitis
- •Primary treatment of periodontal scaling, subgingival curettage is required, and the general progress of the protocol agreed with the basic periodontal therapy patients.
- •subjects agreed collecting saliva and gingival crevicular fluid and physicochemical tests and genetic testing
- •C. Healthy Control
- •Healthy periodontal patients ( more than 20 permanent teeth are present , in all parts of deep periodontal pockets measuring 4mm or less, and height is 2mm or less clinical attachment person)
- •subjects agreed collecting saliva and gingival crevicular fluid and physicochemical tests and genetic testing
排除标准
- •Received periodontal treatment within the last six months
- •recently taken antibiotics within 3 months if you need a prescription antibiotic prophylaxis
- •taking the drug can affect periodontal status for a long period of time
- •pregnant or breastfeeding
- •In case of oral inflammatory mucosal disease (Lichen planus, etc.)
- •A history of alcoholism or drug abuse if
- •other special systemic disease (high blood pressure)
- •ages under 18
研究组 & 干预措施
Moderate periodontitis group
non-surgical periodontal therapy
干预措施: non-surgical periodontal therapy (Procedure)
healthy control
No treatment
severe periodontitis group
non-surgical periodontal therapy
干预措施: non-surgical periodontal therapy (Procedure)
结局指标
主要结局
Expression level of MicroRNAs using Microarray
时间窗: Change from Baseline in expression level of MicroRNAs at 1,6,12 months
次要结局
- Expression level of cytokines using multiple cytokine analysis(Change from Baseline in expression level of cytokines at 1,6,12 months)
研究者
Su-Hwan Kim
Assistant Professor
Asan Medical Center