Efficacy of Guduchi Musta churn as an add-on medicine to Lifestyle modification in childhood sthaulya (overweight) -A comparative clinical trial

Childhood overweight is one of the major problem with increasing prevalence. Excessive body weight is associated with various diseases and potential cause for various social and psychological problems. It is a chronic metabolic condition characterized by abnormal or excessive fat accumulation arising from an imbalance between energy intake and expenditure. Rapidly changing dietary habits & lifestyle have led to increasing prevalence of childhood overweight. Children having BMI percentile Between 85th - 95th are considered overweight. Childhood overweight is considered as one of the most serious health issue worldwide.  As per the modern science the pathophysiology of overweight primarily involves an imbalance between energy intake and expenditure, leading to excess fat deposition in adipose tissue. Adipocyte hypertrophy and hyperplasia cause altered secretion of adipokines which regulate appetite and metabolism. elevated free fatty acids and pro-inflammatory cytokines induce insulin resistance, contributing to metabolic syndrome. Genetic susceptibility also plays key roles in disease progression. Monogenic forms of obesity have also been identified, including MC4R deficiency ,associated with early onset obesity and food seeking behavior. Epigenetics environmental modification of gene may have a role in the development of obesity, especially during fetal and early life.According to Ayurveda, as described by Acharya charka sthaulya is one of the eight disgraceful Persons Difficult to cure designated as Ashtanindita Purush. Sthaulya is one of them. Sthaulya is defined as persons who has excessive accumulation of meda and mansdhatu especially over stana, uder, nitamb. It is one of the Santarpanottha Vikaras and & Shleshma Nanatmaja Vikaras. Etiopathogenosis, prognosis & management of overweight is very similar to Medorog. sthaulya is mostly found in people with predominant kapha type constitution (kapha prakruti) Ayurvedic formulations, Panchkarma therapy, Yogasana, pranayama, along with pathya apathhya (dietary & Lifestyle modification) are explained under treatment of Sthaulya. Guduchi and Musta are Kaph Shyamak, agnivrudhikar. The purpose of this research is to the study the effect of Guduchi Musta Churna in Medoroga in comparison with lifestyle Modification. As per Ayurveda, in Santarpanottha Vikaras Apatarpana is the Prime therapy to treat Sthaulya in wich three main treatments are mentioned that are swedana, langhana and rukshana this treatment reduces sthaulya effectively. These properties are present in Guduchi and musta hence this drugs selected for the study. Ayurvedic Formulation can effectively manage childhood ovenereight without causing any side effects.