Clinical parameters and biomarkers in blood and urine as predictors for bacteremia, hospital admission, morbidity and outcome in patients with complicated urinary tract infections. A study in primary care, the medicine emergency room and ICunit.
Completed
- Conditions
- infection of kidneyPyelonephritis1000401810046590
- Registration Number
- NL-OMON30099
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 600
Inclusion Criteria
- at least one symptom suggestive of urinary tract infection , and
- fever, and
- positive urine nitrate test or
- positive leukocyte esterase test
Exclusion Criteria
- polycystic kidney disease
- end-stage renal failure
- renal transplant
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Clinical cure (resolution of symptoms; determined by diary and follow up after<br /><br>one and three months) and microbiological cure (negative urine culture) after<br /><br>one month. Duration of fever, hospital and/or ICU stay, and outcome, both with<br /><br>respect to course of disease (fever days, development of circulatory shock,<br /><br>multiple organ dysfunction, need of stay in ICU stay and/or urological<br /><br>intervention, number of sick days) as well as recovery or death.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Course of microbiological and host-derived biomarkers in urine and serum,<br /><br>assessed by massspectrometry.</p><br>