ISRCTN75786983已完成未知
Cerebral venous drainage in multiple sclerosis: protocol for a blinded, age-sex matched cross-sectional ultrasound study
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •1. 18 years of age or greater
- •2. Informed consent
- •3. Cases: multiple sclerosis by McDonald criteria with estimated disease severity score < 6, any disease pattern
- •4. Controls: no other relevant health condition
- •5. Ability to perform Valsalva manoeuvre
- •6. Stable disease for one month pre-recruitment
排除标准
- •1. Concurrent enrolment in multiple sclerosis drug trial
- •2. Concurrent masking neurological disease
- •3. Pregnancy
- •4. Inability to lie supine
- •5. Intercurrent infection
- •6. Superior vena cava obstruction
- •7. Tricuspid regurgitation
- •8. Right heart failure
- •9. Vasculitis
- •10. Treatment with venodilators (e.g. nitrates)
- •11. Head and neck surgery or radiotherapy
- •12. Previous central venous catheterisation
- •13. Previous central venous thrombosis
- •14. Thrombophilia
- •15. Arrhythmia on baseline electrocardiogram (ECG)
- •16. Postural systolic drop of >30mmHg on standing
- •17. Steroid treatment within one month
- •18. Pulmonary hypertension
- •19. Malignancy
研究者
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