eukocyte- and Platelet-Rich Fibrin for preventing Osteoradionecrosis following Tooth Extractio

Not Applicable

• Conditions: Osteoradionecrosis; C26.733.579

• Registration Number: RBR-8y49vf
• Lead Sponsor: niversidade Ibirapuera

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-07-02
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Previous 3D conformational radiotherapy for head and neck cancer; total radiotherapy dose from 50Gy to 70Gy; at least 18 years of age; able to undergo dental surgery.

Exclusion Criteria

Disease recurrence (cancer); drugs that impact on tissue repair, healing processes (hard and/or soft tissues), and blood coagulation; diseases that impact on tissue repair, healing processes (hard and/or soft tissues), and blood coagulation; tobacco use; radiotherapy for head and neck cancer more than once.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the potential effect of Leukocyte- and platelet-rich fibrin on preventing the development of tooth extraction related-osteoradionecrosis sites in patients previously submitted to head and neck cancer radiotherapy<br><br>

Secondary Outcome Measures

Name	Time	Method
To evaluate the potential effect of Leukocyte- and platelet-rich fibrin on reducing pain (assessed via visual analogue scale) and other complications of tooth extraction (clinical features) in patients previously submitted to radiotherapy for head and neck cancer