Quality in Patients With Permanent Hypoparathyroidism After Total Thyroidectomy

• Conditions: Permanent Hypoparathyroidism

• Registration Number: NCT04998968
• Lead Sponsor: Uppsala University

Brief Summary

Quality of life study. The study with include all patients operated with total thyroidectomy between 2005-2015 in Uppsala-Örebro healthcare region, Sweden. The study population has been identified in a previous study and includes close to 1700 patients, of which about 200 developed permanent hypoparathyroidism after surgery.

Quality of Life will be assessed using SF-36 Health Surgery and the outcome for patients with and without permanent hypoparathyroidism will be compared.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-08
• Study First Submitted: 2021-08-09
• Study First Submitted QC: 2021-08-09
• Study First Posted: 2021-08-10
• Last Update Submitted: 2021-08-24
• Last Update Posted: 2021-08-25
• Study Start: 2021-09-01
• Primary Completion: 2021-12-31
• Study Completion: 2022-05-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1700

Inclusion Criteria

• Total thyroidectomy between 2005-2015 in Uppsala-Orebro healthcare region.

Exclusion Criteria

• Malignancy
• Sternotomy
• Previous thyroid surgery
• Previous or concurrent parathyroidectomy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quality of Life using SF-36 short form	2021	The SF-36 yields eight scale scores and two summary scores, the physical component summary (PCS) and mental component summary (MCS). Scoring PCS and MCS involves three steps: 1) standardization of the scales (z-scores) 2) aggregation of score scales and 3) transformation of summary scores (t-scores). For each domain (PCS and MCS) the mean score is 50 with a standard deviation of 10. Higher scores indicates better quality of life (score range 0-100)

Trial Locations

Locations (1)

Uppsala University Hospital; 🇸🇪 Uppsala, Sweden