Can better tests improve the right use of antibiotics in respiratory infections?

Not Applicable

• Conditions: Pneumonia, Lower respiratory tract infection; Respiratory

• Registration Number: ISRCTN35745418
• Lead Sponsor: HS Lothian

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-07-18
• Last Update Posted: 26 August 2019
• Study Completion: 2021-06-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: Not specified
• Target Recruitment: 600

Inclusion Criteria

1. Aged 18 and over
2. Hospitalised
3. Lower respiratory tract specimen taken for routine microbiology within 48 hours of admission and - 3 or more of following signs or symptoms of respiratory tract infection:
-new or worsening cough
-new or worsening expectoration of sputum
-haemoptysis
-new or worsening dyspnea
-pleuritic chest pain
-fever
-headache
-abnormalities on chest auscultation or percussion

Exclusion Criteria

1. Hospitalisation for more than 48 hours
2. No capacity to consent
3. Active malignancy
4. Immunodeficiency - defined as being on long term (?28 days) oral prednisolone 10mg or more per day or other long term disease modifying drug
5. Solid organ transplant
6. All forms of pulmonary fibrosis including usual interstitial pneumonia, asbestosis, non-specific interstitial pneumonia, hypersensitivity pneumonitis, active sarcoidosis
7. Palliative treatment only
8. Mechanical ventilation
9. End of life care
10. Previously randomised into this trial
11. Participation in another CTIMP or CIMD interventional study

Study & Design

• Study Type: Interventional
• Study Design: Not specified