NCT00548002已完成不适用
Combination Therapy With Fluoroquinolone in Staphylococcus Aureus Bacteremia
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 430
- 试验地点
- 1
- 主要终点
- Case fatality rate
研究概览
简要总结
To study whether fluoroquinolone (trovafloxacin or levofloxacin), added to standard treatment, could reduce the high mortality and complication rates in Staphylococcus aureus bacteremia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients with at least 1 blood culture positive for Staphylococcus aureus were included within 1 to 7 days of blood culture sampling.
排除标准
- •age younger than 18 years
- •imprisonment
- •proven or suspected pregnancy
- •breastfeeding, epilepsy
- •another bacteremia during the previous 28 days
- •polymicrobial bacteremia (_>3 microbes)
- •history of allergy to any quinolone antibiotic
- •previous tendinitis during fluoroquinolone therapy
- •prior fluoroquinolone use for more than 5 days before randomization
- •positive culture for Staphylococcus aureus only from a central intravenous catheter
- •neutropenia (<0.5 x 109/L) or failure to supply an informed consent
- •patients with bacteremia due to methicillin-resistant S. aureus and a S. aureus strain resistant to any fluoroquinolone
- •patients with meningitis at the time of randomization
研究组 & 干预措施
1 and 2
Patients were randomly assigned to receive either 1) standard treatment or 2) standard treatment combined with a fluoroquinolone (trovafloxacin or levofloxacin).
干预措施: trovafloxacin and levofloxacin (Drug)
结局指标
主要结局
Case fatality rate
时间窗: At 28 days and at 3 months
次要结局
- The number of complications (e.g. deep infections) observed after the first week antibiotic treatment, decrease in serum C-reactive protein concentration, length of antibiotic treatment, need for surgical intervention, and time to defervescence.(3 months)
研究者
研究点 (1)
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