Proton pump inhibitors in the prevention of iron reaccumulation in patients with hereditary hemochromatosis
Completed
- Conditions
- hereditary hemochromatosis/ ironreaccumulation disease10022958
- Registration Number
- NL-OMON38058
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 28
Inclusion Criteria
Patient with hereditairy hemochromatosis, homozygous for c282Y currently treated with phlebotomy as maintenance therapy for at least 12 months with >/<= phlebotomies per year.;Ferritin level between 50-100 ug/l at start of inclusion.;Age 18-75 years;Weight > 50kg
Exclusion Criteria
Patients receiving other therapies such as chelating therapy or forced diet;Obesitas (BMI > 35);Patients who are mentally incapacitated;pregnancy; women expecting / planning to become pregnant during the study period.;Patients with a malignancy;Patients already on ppi treatment;patients experienced side effects ppi.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The total number of phlebotomies for the group taking PPI treatment compared to<br /><br>the group taking placebo </p><br>
- Secondary Outcome Measures
Name Time Method <p>Quality of life<br /><br>Cost-effectiveness<br /><br>Patient satisfaction<br /><br>Side effects of treatment (PPI)</p><br>